About: Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The antiviral active boron cluster [3-cobalt bis(1,2-dicarbollide)](-1) anion, CoD, interacts and forms a stable complex with one of the most widely used polymeric component of drug delivery systems: poly(ethylene oxide), PEO. The formation of insoluble NaCoD/PEO complex can be exploited in design of water-soluble metallacarborane-containing nanoparticles that could offer applications in medicine. We studied the boron cluster interaction with a hydrophilic block copolymer: poly(ethylene oxide)-block-poly(methacrylic acid), PEO-PMA. The interaction leads to a spontaneous formation of core-shell nanoparticles. The insoluble core contains the PEO/CoD complex, while the polyanionic PMA blocks, which do not interact with the metallacarborane, form the pH-responsive micellar shell and stabilize the particles in aqueous media. The antiviral active boron cluster [3-cobalt bis(1,2-dicarbollide)](-1) anion, CoD, interacts and forms a stable complex with one of the most widely used polymeric component of drug delivery systems: poly(ethylene oxide), PEO. The formation of insoluble NaCoD/PEO complex can be exploited in design of water-soluble metallacarborane-containing nanoparticles that could offer applications in medicine. We studied the boron cluster interaction with a hydrophilic block copolymer: poly(ethylene oxide)-block-poly(methacrylic acid), PEO-PMA. The interaction leads to a spontaneous formation of core-shell nanoparticles. The insoluble core contains the PEO/CoD complex, while the polyanionic PMA blocks, which do not interact with the metallacarborane, form the pH-responsive micellar shell and stabilize the particles in aqueous media. (en)
Title	Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide) Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide) (en)
skos:prefLabel	Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide) Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide) (en)
skos:notation	RIV/61389013:_____/09:00327533!RIV10-AV0-61389013
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1ET400500402), P(GD203/05/H001), P(GP203/06/P138), P(GP203/06/P261), P(IAAX00320901), Z(AV0Z40500505), Z(AV0Z40550506), Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	13
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pleštil, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	343850
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/09:00327533
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	block-copolymer micelles; light-scattering; dicarbollide anions (en)
http://linked.open.../riv/klicoveSlovo	block-copolymer micelles dicarbollide anions light-scattering
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3B2B51CB5A36]
http://linked.open...i/riv/nazevZdroje	Macromolecules
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Functionalized boron clusters as viral enzyme inhihitors Experimental Study and Computer Modeling of the Structure and Function of the Complex Molecular Systems and Bio(macro)molecules Computer modelling of chmical structures for the design of macromolecular systems with new biological, mechanical and electronic properties Interaction of colloidal particles with polymers Capillary zone electrophoresis of the chiral compounds - computer prediction of the separation
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	42
http://linked.open...iv/tvurceVysledku	Hobza, Pavel Procházka, K. Fanfrlík, Jindřich Matějíček, P. Pleštil, Josef Zedník, J. Nykanen, A. Ruokolainen, J. Ušelová, K.
http://linked.open...ain/vavai/riv/wos	000268138500068
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	0024-9297
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide) Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide) Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide) Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide)

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