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Description
  • One of the promising approaches in the therapy of ulcerative colitis is administration of butyrate, an energy source for colonocytes, into the lumen of the colon. This study investigates the effect of butyrate producing bakterium Clostridium tyrobutyricum on dextran sodium sulphate (DSS)-induced colitis in mice. Immunocompetent BALB/c and immunodeficient severe combined immunodeficiency (SCID) mice reared in specific-pathogen-free (SPF) conditions were treated intrarectally with C. tyrobutyricum 1 week prior to the induction of DSS colitis and during oral DSS treatment. Administration of DSS without C. tyrobutyricum treatment led to an appearance of clinical symptoms – bleeding, rectal prolapses and colitis-induced increase in the antigen CD11b, a marker of infiltrating inflammatory cells in the lamina propria
  • One of the promising approaches in the therapy of ulcerative colitis is administration of butyrate, an energy source for colonocytes, into the lumen of the colon. This study investigates the effect of butyrate producing bakterium Clostridium tyrobutyricum on dextran sodium sulphate (DSS)-induced colitis in mice. Immunocompetent BALB/c and immunodeficient severe combined immunodeficiency (SCID) mice reared in specific-pathogen-free (SPF) conditions were treated intrarectally with C. tyrobutyricum 1 week prior to the induction of DSS colitis and during oral DSS treatment. Administration of DSS without C. tyrobutyricum treatment led to an appearance of clinical symptoms – bleeding, rectal prolapses and colitis-induced increase in the antigen CD11b, a marker of infiltrating inflammatory cells in the lamina propria (en)
Title
  • Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-α and interleukin-18 in BALB/c and severe combined immunodeficiency mice
  • Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-α and interleukin-18 in BALB/c and severe combined immunodeficiency mice (en)
skos:prefLabel
  • Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-α and interleukin-18 in BALB/c and severe combined immunodeficiency mice
  • Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-α and interleukin-18 in BALB/c and severe combined immunodeficiency mice (en)
skos:notation
  • RIV/61388971:_____/12:00377981!RIV13-GA0-61388971
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(2B06155), P(GA303/08/0367), P(GA303/09/0449), P(GAP304/11/1252), P(ME10017), Z(AV0Z50110509), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 163050
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/12:00377981
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • butyrate; Clostridium tyrobutyricum; confocal fluorimetry (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [3A83C4BC4060]
http://linked.open...i/riv/nazevZdroje
  • Clinical and Experimental Immunology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 167
http://linked.open...iv/tvurceVysledku
  • Tlaskalová-Hogenová, Helena
  • Řezanka, Tomáš
  • Klepetář, Jan
  • Kozáková, Hana
  • Schwarzer, Martin
  • Šrůtková, Dagmar
  • Hudcovic, Tomáš
  • Erban, V.
  • Hrnčíř, Tomáš
  • Štěpánková, Renata
  • Du, Zhengyu
  • Kolínská, Jiřina
  • Wells, J. M.
http://linked.open...ain/vavai/riv/wos
  • 000299037700021
http://linked.open...n/vavai/riv/zamer
issn
  • 0009-9104
number of pages
http://bibframe.org/vocab/doi
  • 10.1111/j.1365-2249.2011.04498.x
is http://linked.open...avai/riv/vysledek of
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