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| rdf:type
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| rdfs:seeAlso
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| Description
| - The major goal of this proposal is to study the role of probiotic bacterial strains Gram+ (Lactobacilli) and Gram- (non-pathogenic Escherichia coli) on the regulation of cytokine expression, signaling molecules NF-κB and p38 MAPK and apoptotic markers (Bax, Akt, Bcl2) in IEC-18 cells on the tranional and translational levels. This IEC-18 cell line is derived from rat ileum, the distal part of the small intestine mostly affected by inflammation. Cytokines and chemokines (such as IL-18, IL-6, IL-8, MCP-1, MIP-1alpha, MIP-1beta constitutively expressed by IEC-18 cells will be evaluated in these studies. In addition, gene and protein expression of family of TLR receptors and tight junction proteins will be evaluated. Activation of associate signaling pathways in epithelial cells as a result of exposure to probiotic bacteria will be studied. (en)
- Studium vlivu probiotických bakterií na regulaci a expresi zánětlivých cytokinů epiteliálními buňkami prostřednictvím TLR receptorů a signalizačních drah. Ovlivnění apoptických dějů v buňkách střevní sliznice probiotiky.
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| Title
| - Role of probiotic bacteria in the regulation of intestinal epithelial cell functions (en)
- Role probiotických bakterií v regulaci funkcí střevních epiteliálních buněk
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - IEC-18 line; probiotics; cytokines; chemokines; signaling pathways; Toll-receptors; tight junctions; inflammatory bowel diseases (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - This project was designed to study effects of medically important bacterial strains. The results point to some new molecular mechanisms of therapeutic function of non-pathogenic bacteria at the appearance, prevention and therapy of intestinal inflammation. This was shown by elucidation of signal cascades of production and activation of pro-inflammatory cytokines. (en)
- Projekt byl zaměřen na lékařsky aktuální nepatogenní bakteriální kmeny. Výsledky projektu ukazují na nové molekulární mechanizmy terapeutického působení těchto bakterií, při vzniku, prevenci a terapii zánětlivých onemocnění střeva, především objasněním signalizační kaskády tvorby a aktivace zánětlivých cytokinů. (cs)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - chemokines
- cytokines
- probiotics
- Toll-receptors
- signaling pathways
- tight junctions
- IEC-18 line
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| is http://linked.open...vavai/riv/projekt
of | |
| is http://linked.open...vavai/cep/projekt
of | |
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