About: Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II)

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Flavonolignans, silybin and its derivatives (2,3-dehydrosilybin, 7-O-methylsilybin, 20-O-methylsilybin) and isosilybin were studied using ex situ (adsorptive transfer, AdT) cyclic and square wave voltammetry (SWV). The two oxidation steps were described for flavonolignans at potentials Ep1 +0.5 V and Ep2 +0.85 V depending on experimental conditions. An additional oxidation peak at Ep3 +0.35 V was observed only for 2,3-dehydrosilybin. The anodic currents of flavonolignans are related to their electron transfer processes (oxidation of hydroxyl groups), which was supported by density functional theory (DFT) and B3P86 theory level. Our electrochemical results confirmed that 2,3-dehydrosilybin is a relatively strong antioxidant, which is strictly associated with oxidation at Ep3 Flavonolignans, silybin and its derivatives (2,3-dehydrosilybin, 7-O-methylsilybin, 20-O-methylsilybin) and isosilybin were studied using ex situ (adsorptive transfer, AdT) cyclic and square wave voltammetry (SWV). The two oxidation steps were described for flavonolignans at potentials Ep1 +0.5 V and Ep2 +0.85 V depending on experimental conditions. An additional oxidation peak at Ep3 +0.35 V was observed only for 2,3-dehydrosilybin. The anodic currents of flavonolignans are related to their electron transfer processes (oxidation of hydroxyl groups), which was supported by density functional theory (DFT) and B3P86 theory level. Our electrochemical results confirmed that 2,3-dehydrosilybin is a relatively strong antioxidant, which is strictly associated with oxidation at Ep3 (en)
Title	Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II) Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II) (en)
skos:prefLabel	Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II) Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II) (en)
skos:notation	RIV/61388971:_____/11:00370938!RIV12-AV0-61388971
http://linked.open...avai/predkladatel	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GAP301/10/0883), P(GAP301/11/0767), P(GD303/09/H048), P(GPP503/11/P312), S, Z(AV0Z50200510), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Gažák, Radek Křen, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	197035
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/11:00370938
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Flavonolignans; Antioxidants; Flavonols (en)
http://linked.open.../riv/klicoveSlovo	Antioxidants Flavonolignans Flavonols
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[FCA6AF54E0B9]
http://linked.open...i/riv/nazevZdroje	Bioelectrochemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of selected pathological processes in the cell Nephrotoxicity of cisplatin – role of the Na+/K+-ATPase Modulation of intestinal inflammation and nitric oxide production by quercetin and its conjugates Examination of safety of the alkaloids from Macleaya cordata by study their interactions with DNA using modern analytical tools
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	82
http://linked.open...iv/tvurceVysledku	Gažák, Radek Křen, Vladimír Trouillas, P. Kubala, M. Ulrichová, J. Vacek, J. Zatloukalová, M.
http://linked.open...ain/vavai/riv/wos	000296946100006
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1567-5394
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bioelechem.2011.06.005
is http://linked.open...avai/riv/vysledek of	Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II) Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II)

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