About: Large-scale separation of silybin diastereoisomers using lipases

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The flavonolignan silybin (1), isolated from the seeds of milk thistle (Silybum marianum), occurs in nature as an equimolar mixture of two diastereoisomers, silybin A and silybin B, that exhibit different biological activities. The preparative production of optically pure silybin A and B in a diastereoisomeric purity greater than 95 percent was accomplished using immobilized Candida antarctica lipase B (Novozym 435) in a combination of two reactions: regioselective acetylation of a natural silybin mixture (1) and subsequent stereoselective alcoholysis of the resulting 23-O-acetylsilybin (2). Several grams of the optically pure substances can be produced within one week using this new, robust and scalable process, which is selective, mild and high-yielding The flavonolignan silybin (1), isolated from the seeds of milk thistle (Silybum marianum), occurs in nature as an equimolar mixture of two diastereoisomers, silybin A and silybin B, that exhibit different biological activities. The preparative production of optically pure silybin A and B in a diastereoisomeric purity greater than 95 percent was accomplished using immobilized Candida antarctica lipase B (Novozym 435) in a combination of two reactions: regioselective acetylation of a natural silybin mixture (1) and subsequent stereoselective alcoholysis of the resulting 23-O-acetylsilybin (2). Several grams of the optically pure substances can be produced within one week using this new, robust and scalable process, which is selective, mild and high-yielding (en)
Title	Large-scale separation of silybin diastereoisomers using lipases Large-scale separation of silybin diastereoisomers using lipases (en)
skos:prefLabel	Large-scale separation of silybin diastereoisomers using lipases Large-scale separation of silybin diastereoisomers using lipases (en)
skos:notation	RIV/61388971:_____/10:00348130!RIV11-GA0-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/08/0658), P(GAP207/10/0288), P(LC06010), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Gažák, Radek Biedermann, David Křen, Vladimír Marhol, Petr Purchartová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	267910
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/10:00348130
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Silybin A; silymarin; silibinin (en)
http://linked.open.../riv/klicoveSlovo	silibinin silymarin Silybin A
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A8CA966FBF33]
http://linked.open...i/riv/nazevZdroje	Process Biochemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Biocatalysis and Biotransformation Isosilybin: Combined chemo-enzymatic approaches for preparation of optically pure stereoisomers and derivatives. Modulation of uncoupling protein UcP2 and mitochondrial bioenergetics in cardiomyocytes by natural substances
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	45
http://linked.open...iv/tvurceVysledku	Gažák, Radek Křen, Vladimír Monti, D. Riva, S. Marhol, Petr Purchartová, Kateřina Biedermann, David Cvak, L.
http://linked.open...ain/vavai/riv/wos	000282388800009
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	1359-5113
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Large-scale separation of silybin diastereoisomers using lipases

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