About: The 14-3-3 Protein Affects the Conformation of the Regulatory Domain of Human Tyrosine Hydroxylase

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tyrosine hydroxylase (TH) catalyzes the first step in the biosynthesis of catecholamines. The main goal of this work was to investigate whether the 14-3-3 protein binding affects the conformation of the regulatory domain of human TH isoform 1 (TH1R). The 14-3-3 protein binding also reduces the sensitivity of phosphorylated TH1R to proteolysis by protecting its N-terminal part (first 33 residues) Tyrosine hydroxylase (TH) catalyzes the first step in the biosynthesis of catecholamines. The main goal of this work was to investigate whether the 14-3-3 protein binding affects the conformation of the regulatory domain of human TH isoform 1 (TH1R). The 14-3-3 protein binding also reduces the sensitivity of phosphorylated TH1R to proteolysis by protecting its N-terminal part (first 33 residues) (en) tyrosinhydroxylasa (TH) katalyzuje první krok v biosyntéze katecholaminů. Hlavním cílem této práce bylo zjistit, zda vazba 14-3-3 proteinu ovlivňuje konformaci regulační domény lidské TH isoformy 1 (TH1R). Vazba 14-3-3 proteinu také reguluje citlivost fosforylovaných TH1R k proteolýze ochranou N-koncového segmentu (prvních 33 zbytků) (cs)
Title	The 14-3-3 Protein Affects the Conformation of the Regulatory Domain of Human Tyrosine Hydroxylase The 14-3-3 Protein Affects the Conformation of the Regulatory Domain of Human Tyrosine Hydroxylase (en) 14-3-3 protein ovlivňuje konformaci regulační domény lidské tyrosinhydroxylasy (cs)
skos:prefLabel	The 14-3-3 Protein Affects the Conformation of the Regulatory Domain of Human Tyrosine Hydroxylase The 14-3-3 Protein Affects the Conformation of the Regulatory Domain of Human Tyrosine Hydroxylase (en) 14-3-3 protein ovlivňuje konformaci regulační domény lidské tyrosinhydroxylasy (cs)
skos:notation	RIV/61388971:_____/08:00315910!RIV09-AV0-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/06/0565), P(KJB500110601), P(LC554), Z(AV0Z50110509), Z(AV0Z50200510), Z(MSM0021620835), Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Šulc, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	407524
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/08:00315910
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	14-3-3 protein; tyroxine hydroxylase; fluorescence (en)
http://linked.open.../riv/klicoveSlovo	tyroxine hydroxylase fluorescence 14-3-3 protein
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C35F8850A239]
http://linked.open...i/riv/nazevZdroje	Biochemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Neuroscience Centre Role of the phosphorylation and the 14-3-3 protein binding in the regulation of signaling complexes function Study of the function of 14-3-3 protein isoforms C-terminal segments.
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Obšil, Tomáš Teisinger, Jan Šulc, Miroslav Bouřa, Evžen Herman, P. Obšilová, Veronika Večeř, J. Šilhán, Jan Nedbálková, Eliška Dyda, F.
http://linked.open...ain/vavai/riv/wos	252940600031
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Microorganisms in Research and Biotechnology Fyzika molekulárních, makromolekulárních a biologických systémů Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	0006-2960
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The 14-3-3 Protein Affects the Conformation of the Regulatory Domain of Human Tyrosine Hydroxylase The 14-3-3 Protein Affects the Conformation of the Regulatory Domain of Human Tyrosine Hydroxylase The 14-3-3 Protein Affects the Conformation of the Regulatory Domain of Human Tyrosine Hydroxylase The 14-3-3 Protein Affects the Conformation of the Regulatory Domain of Human Tyrosine Hydroxylase

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