About: Pore-Forming and Enzymatic Activities of Bordetella pertussis Adenylate Cyclase Toxin Synergize in Promoting Lysis of Monocytes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We used here the non-acylated proCyaA, unable to form membrane pores, and the specific CyaA mutants exhibiting a selectively reduced hemolytic activity but full capacity to elevate cAMP in cells, to corroborate the observation that enzymatic depletion of cellular ATP due to toxin action is sufficient to promote cell death and lysis. It is further shown, that pore-forming (hemolytic) activity of CyaA synergizes with the invasive AC enzyme activity in maximizing the overall cytolytic potency of the toxin We used here the non-acylated proCyaA, unable to form membrane pores, and the specific CyaA mutants exhibiting a selectively reduced hemolytic activity but full capacity to elevate cAMP in cells, to corroborate the observation that enzymatic depletion of cellular ATP due to toxin action is sufficient to promote cell death and lysis. It is further shown, that pore-forming (hemolytic) activity of CyaA synergizes with the invasive AC enzyme activity in maximizing the overall cytolytic potency of the toxin (en) Použili jsme neacylovaný proCyaA, který netvoří membránové póry, a specifické CyaA mutanty vykazující selektivně sníženou hemolytickou aktivitu, ale mající plnou schopnost zvyšovat cAMP v buňkách, k podpoření pozorování, že enzymatická deplece buněčného ATP díky akci toxinu je dostačující ke způsobení buněčné smrti a buněčné lyze. Dále jsme ukázali, že hemolytická aktivita CyaA synergizuje s invazivní AC aktivitou a tím maximalizuje celkovou cytolytickou aktivitu toxinu (cs)
Title	Pore-Forming and Enzymatic Activities of Bordetella pertussis Adenylate Cyclase Toxin Synergize in Promoting Lysis of Monocytes Pore-Forming and Enzymatic Activities of Bordetella pertussis Adenylate Cyclase Toxin Synergize in Promoting Lysis of Monocytes (en) Kanálotvorná a enzymatická aktivita Adenylát cyklázového toxinu Bordetella pertussis synergizují v působení lyze monocytů (cs)
skos:prefLabel	Pore-Forming and Enzymatic Activities of Bordetella pertussis Adenylate Cyclase Toxin Synergize in Promoting Lysis of Monocytes Pore-Forming and Enzymatic Activities of Bordetella pertussis Adenylate Cyclase Toxin Synergize in Promoting Lysis of Monocytes (en) Kanálotvorná a enzymatická aktivita Adenylát cyklázového toxinu Bordetella pertussis synergizují v působení lyze monocytů (cs)
skos:notation	RIV/61388971:_____/06:00040415!RIV07-MSM-61388971
http://linked.open.../vavai/riv/strany	2207;2214
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0506), P(IAA5020406), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Osička, Radim Basler, Marek Šebo, Peter Mašín, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	492988
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/06:00040415
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bordetella pertussis; cyaa; cytotoxicity (en)
http://linked.open.../riv/klicoveSlovo	cytotoxicity bordetella pertussis cyaa
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D9EC778CE1C6]
http://linked.open...i/riv/nazevZdroje	Infection and Immunity
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Molecular and Cellular Immunology Mechanisms of membrane interaction and cytotoxic activity of adenylate cyclase
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	74
http://linked.open...iv/tvurceVysledku	Osička, Radim Šebo, Peter Basler, Marek Mašín, Jiří
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0019-9567
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Pore-Forming and Enzymatic Activities of Bordetella pertussis Adenylate Cyclase Toxin Synergize in Promoting Lysis of Monocytes Pore-Forming and Enzymatic Activities of Bordetella pertussis Adenylate Cyclase Toxin Synergize in Promoting Lysis of Monocytes

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