About: Acylation of Lysine 860 Allows Tight Binding and Cytotoxicity of Bordetella Adenylate Cyclase on CD1 1b-Expressing Cells

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About: Acylation of Lysine 860 Allows Tight Binding and Cytotoxicity of Bordetella Adenylate Cyclase on CD1 1b-Expressing Cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The Bordetella adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) forms cation-selective membrane channels and delivers into the cytosol of target cells an adenylate cyclase domain (AC) that catalyzes uncontrolled conversion of cellular ATP to cAMP. Both toxin activities were previously shown to depend on post-translational activation of proCyaA to CyaA by covalent palmitoylation of the internal Lys983 residue (K983). CyaA, however, harbors a second RTX acylation site at residue Lys860 (K860), and the role of K860 acylation in toxin activity is unclear The Bordetella adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) forms cation-selective membrane channels and delivers into the cytosol of target cells an adenylate cyclase domain (AC) that catalyzes uncontrolled conversion of cellular ATP to cAMP. Both toxin activities were previously shown to depend on post-translational activation of proCyaA to CyaA by covalent palmitoylation of the internal Lys983 residue (K983). CyaA, however, harbors a second RTX acylation site at residue Lys860 (K860), and the role of K860 acylation in toxin activity is unclear (en) Práce ukazuje, že jediná acylace jak na lysinu 860 tak na lysinu 983 postačuje pro těsnou interakci ACT s integrinovým receptorem CD11b/CD18. Tato funkční redundance dvou acylačních míst nemá zřejmý důvod, nicméně umožňuje průnik toxinu do buněk přes plasmatickou membránu (cs)
Title	Acylation of Lysine 860 Allows Tight Binding and Cytotoxicity of Bordetella Adenylate Cyclase on CD1 1b-Expressing Cells Acylace lysinového zbytku 860 umožňuje pevnou vazbu a cytotoxickou aktivitu adenylát-cyklazového toxinu baktérie Bordetella pertussis na buňkách exprimunjících CD11b (cs) Acylation of Lysine 860 Allows Tight Binding and Cytotoxicity of Bordetella Adenylate Cyclase on CD1 1b-Expressing Cells (en)
skos:prefLabel	Acylation of Lysine 860 Allows Tight Binding and Cytotoxicity of Bordetella Adenylate Cyclase on CD1 1b-Expressing Cells Acylace lysinového zbytku 860 umožňuje pevnou vazbu a cytotoxickou aktivitu adenylát-cyklazového toxinu baktérie Bordetella pertussis na buňkách exprimunjících CD11b (cs) Acylation of Lysine 860 Allows Tight Binding and Cytotoxicity of Bordetella Adenylate Cyclase on CD1 1b-Expressing Cells (en)
skos:notation	RIV/61388971:_____/05:00022198!RIV06-AV0-61388971
http://linked.open.../vavai/riv/strany	12766;12759
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0506), P(IAA5020406), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Basler, Marek Šebo, Peter Mašín, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	511341
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/05:00022198
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lysine 860; bordetella (en)
http://linked.open.../riv/klicoveSlovo	bordetella lysine 860
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[60E0FCBB0C55]
http://linked.open...i/riv/nazevZdroje	Biochemistry
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Molecular and Cellular Immunology Mechanisms of membrane interaction and cytotoxic activity of adenylate cyclase
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Šebo, Peter Konopásek, I. Basler, Marek Mašín, Jiří Leclerc, C. Benz, R. Knapp, O. Maier, E. El-Azami-El-Idrissi, M.
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0006-2960
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Acylation of Lysine 860 Allows Tight Binding and Cytotoxicity of Bordetella Adenylate Cyclase on CD1 1b-Expressing Cells

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