About: Direct C-H arylation of purines and purine nucleosides

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bylo dosaženo přímé C-H arylace purinů v poloze 8 různými aryl halidy pomocí palladiové katalýzy za přítomnosti CuI a Cs2CO3. Tato metoda, v kombinaci se dvěma cross-coupling reakcemi, byla aplikována v postupné regioselektivní syntéze 2,6,8-trisubstituovaných purinů nesoucích tři odlišné C-substituenty. Byla vyvinuta metoda přímé arylace nechráněných purinových nukloesidů aryl jodidy umožňující jednokrokové zavedení arylové skupiny. (cs) Direct C–H arylation of purines to position 8 by diverse aryl halides was achieved using Pd catalysis in the presence of CuI and Cs2CO3. The methodology was applied in consecutive regioselective synthesis of 2,6,8-trisubstituted purines bearing three different C-substituents in combination with two cross-coupling reaction. In addition, direct arylation of unprotected purine nucleosides with aryl iodides at position 8 was developed to allow straightforward single-step introduction of diverse aryl groups. Direct C–H arylation of purines to position 8 by diverse aryl halides was achieved using Pd catalysis in the presence of CuI and Cs2CO3. The methodology was applied in consecutive regioselective synthesis of 2,6,8-trisubstituted purines bearing three different C-substituents in combination with two cross-coupling reaction. In addition, direct arylation of unprotected purine nucleosides with aryl iodides at position 8 was developed to allow straightforward single-step introduction of diverse aryl groups. (en)
Title	Direct C-H arylation of purines and purine nucleosides Přímá C-H arylace purinů a purinových nukleosidů (cs) Direct C-H arylation of purines and purine nucleosides (en)
skos:prefLabel	Direct C-H arylation of purines and purine nucleosides Přímá C-H arylace purinů a purinových nukleosidů (cs) Direct C-H arylation of purines and purine nucleosides (en)
skos:notation	RIV/61388963:_____/08:00309916!RIV09-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/05/0043), P(LC06077), Z(AV0Z40550506)
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Hocek, Michal Čerňa, Igor
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	363730
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/08:00309916
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	C-H activation; nucleosides; cross-coupling (en)
http://linked.open.../riv/klicoveSlovo	cross-coupling nucleosides C-H activation
http://linked.open...ontrolniKodProRIV	[95CDAD731B27]
http://linked.open...v/mistoKonaniAkce	Český Krumlov
http://linked.open...i/riv/mistoVydani	Praha
http://linked.open...i/riv/nazevZdroje	Chemistry of Nucleic Acid Components
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Chemical Genetics Conjugates of nucleobases with metal complexes as electroactive markers. Application of labelled oligonucleotides in electrochemical DNA sensors
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Hocek, Michal Čerňa, Igor
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open...ain/vavai/riv/wos	000257885700065
http://linked.open.../riv/zahajeniAkce	2008-06-08 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
number of pages	3 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Institute of Organic Chemistry and Biochemistry ASCR
https://schema.org/isbn	978-80-86241-29-6
is http://linked.open...avai/riv/vysledek of	Direct C-H arylation of purines and purine nucleosides Direct C-H arylation of purines and purine nucleosides Direct C-H arylation of purines and purine nucleosides Direct C-H arylation of purines and purine nucleosides

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