About: Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Series of modified nucleosides and oligonucleotides bearing metal complexes were synthetized. Palladium catalyzed aqueous-phase cross-coupling reactions were used as key step in the synthesis of modified metallo-labeled nucleosides, nucleotides and oligonucleotides. The corresponding Fc modified dNTPs were good sustrates for DNA polymerases and were efficiently incorporated to DNA by primer extension (PEX). The modified nucleic acids are applicable as tools in bioanalysis. Series of modified nucleosides and oligonucleotides bearing metal complexes were synthetized. Palladium catalyzed aqueous-phase cross-coupling reactions were used as key step in the synthesis of modified metallo-labeled nucleosides, nucleotides and oligonucleotides. The corresponding Fc modified dNTPs were good sustrates for DNA polymerases and were efficiently incorporated to DNA by primer extension (PEX). The modified nucleic acids are applicable as tools in bioanalysis. (en) Byla připravena série modifikovaných nucleosidů a oligonukleotidů nesoucích komplexy kovů. Paládiem katalyzované cross-coupling reakce byly klíčovým krokem při syntéze modifikovaných kovem-značených nukleosidů, nukleotidů a oligonukleotidů. Příslušné Fc modifikované nukleosid trifosfáty byly dobrými substráty DNA polymeráz a byly úspěšně zabudovány do DNA pomocí primer extenze (PEX). Takto modifikované nukleové kyseliny jsou použitelné jako nástroje pro bioanalýzu. (cs)
Title	Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes Příprava modifikovaných nukleosidů, nukleotidů a oligonukleotidů nesoucích komplexy kovů (cs) Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes (en)
skos:prefLabel	Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes Příprava modifikovaných nukleosidů, nukleotidů a oligonukleotidů nesoucích komplexy kovů (cs) Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes (en)
skos:notation	RIV/61388963:_____/08:00309908!RIV09-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/05/0043), P(LC512), Z(AV0Z40550506)
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Hocek, Michal Vrábel, Milan
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	398784
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/08:00309908
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; electrochemical labels; metal complexes (en)
http://linked.open.../riv/klicoveSlovo	electrochemical labels DNA metal complexes
http://linked.open...ontrolniKodProRIV	[76883894262D]
http://linked.open...v/mistoKonaniAkce	Český Krumlov
http://linked.open...i/riv/mistoVydani	Praha
http://linked.open...i/riv/nazevZdroje	Chemistry of Nucleic Acid Components
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for biomolecules and complex molecular systems Conjugates of nucleobases with metal complexes as electroactive markers. Application of labelled oligonucleotides in electrochemical DNA sensors
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Hocek, Michal Vrábel, Milan
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open...ain/vavai/riv/wos	000257885700028
http://linked.open.../riv/zahajeniAkce	2008-06-08 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Institute of Organic Chemistry and Biochemistry ASCR
https://schema.org/isbn	978-80-86241-29-6
is http://linked.open...avai/riv/vysledek of	Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes

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