About: Synthesis and properties of 2-guanidinopurines     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • 2-Guanidinopuriny byly připraveny jako deriváty 2,6-diamino-9-[2-(fosfonomethoxy)ethyl]-9H-purinu (PMEDAPu), který má významné protivirové účinky. Tato práce je pokračováním strukturně aktivitní studie, která se zabývá vlivem nahrazení aminoskupiny bazičtější guanidino skupinou na protivirovou aktivitu. Bohužel se ukázalo, že žádná z nově syntetizovaných látek nevykazovala protivirovou aktivitu. U syntetizovaných látek byly také stanoveny hodnoty disociačních konstant (pKa) jejich ionogenních skupin metodou kapilární zonové elektroforézy a bylo provedeno porovnání bazicity mezi 6-guanidinopurinovými a 2-guanidinopurinovými deriváty. (cs)
  • 2-Guanidinopurines were prepared as derivatives of 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]-9H-purine (PMEDAP), which shows an important antiviral activity. It completes earlier described synthesis of 6-guanidinopurine derivatives. 2- and 6-guanidinopurines were used as model compounds for determination of dissociation constants (pKa) of their ionogenic groups by capillary zone electrophoresis. The pKa values of ionogenic groups of the above compounds were compared with those of the corresponding aminopurines. None of these compounds showed any antiviral activity.
  • 2-Guanidinopurines were prepared as derivatives of 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]-9H-purine (PMEDAP), which shows an important antiviral activity. It completes earlier described synthesis of 6-guanidinopurine derivatives. 2- and 6-guanidinopurines were used as model compounds for determination of dissociation constants (pKa) of their ionogenic groups by capillary zone electrophoresis. The pKa values of ionogenic groups of the above compounds were compared with those of the corresponding aminopurines. None of these compounds showed any antiviral activity. (en)
Title
  • Synthesis and properties of 2-guanidinopurines
  • Synthesis and properties of 2-guanidinopurines (en)
  • Syntéza a vlastnosti 2-guanidinopurinů (cs)
skos:prefLabel
  • Synthesis and properties of 2-guanidinopurines
  • Synthesis and properties of 2-guanidinopurines (en)
  • Syntéza a vlastnosti 2-guanidinopurinů (cs)
skos:notation
  • RIV/61388963:_____/06:00043507!RIV07-AV0-61388963
http://linked.open.../vavai/riv/strany
  • 1303;1319
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), P(1QS400550501), P(GA203/05/2539), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 502796
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/06:00043507
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • purines; nucleosides; guanidines; basicity (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [EA9809B4C5C3]
http://linked.open...i/riv/nazevZdroje
  • Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 71
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • Kašička, Václav
  • Koval, Dušan
  • Česnek, Michal
  • Masojídková, Milena
  • Šolínová, Veronika
http://linked.open...n/vavai/riv/zamer
issn
  • 0010-0765
number of pages
is http://linked.open...avai/riv/vysledek of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 47 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software