About: Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase     Goto   Sponge   NotDistinct   Permalink

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  • V tomto článku se zabýváme sadou nových 5,6-substituovaných uracilů s prokazatelnou inhibiční aktivitou vůči E. coli a lidské thymidin fosforyláze. Bis-uracilové deriváty se ukázaly jako nejúčinnější inhibitory thymidin fosforyláz v této studii. (cs)
  • We report on a series of novel 5,6-disubstituted uracils with significant inhibitory activity against human and Escherichia coli thymidine phosphorylases. Bis-uracil conjugates were identified as the most potent inhibitors of TPs in this study.
  • We report on a series of novel 5,6-disubstituted uracils with significant inhibitory activity against human and Escherichia coli thymidine phosphorylases. Bis-uracil conjugates were identified as the most potent inhibitors of TPs in this study. (en)
Title
  • Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase
  • Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase (en)
  • Design a syntéza nových 5,6-substituovaných uracilových derivátů jako účinných inhibitorů thymidin fosforylázy (cs)
skos:prefLabel
  • Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase
  • Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase (en)
  • Design a syntéza nových 5,6-substituovaných uracilových derivátů jako účinných inhibitorů thymidin fosforylázy (cs)
skos:notation
  • RIV/61388963:_____/06:00042155!RIV07-AV0-61388963
http://linked.open.../vavai/riv/strany
  • 1335;1337
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA203/03/0089), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 470908
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/06:00042155
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • thymidine phosphorylase inhibitor; disubstituted uracils; angiogenesis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [1C63BDCFE51C]
http://linked.open...i/riv/nazevZdroje
  • Bioorganic and Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 16
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • Hřebabecký, Hubert
  • Nencka, Radim
  • Votruba, Ivan
  • Tloušťová, Eva
  • Masojídková, Milena
  • Horská, Květoslava
http://linked.open...n/vavai/riv/zamer
issn
  • 0960-894X
number of pages
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