About: The RNA binding G-patch domain in retroviral protease is important for infectivity and D-type morphogenesis of Mason-Pfizer monkey virus

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	C-koncové sekvence M-PMV proteasy obsahují motiv bohatý na glycin (G-patch), který váže in vitro jednořetězcové nukleové kyseliny. Ukázali jsme, že tato doména proteasy neovlivňuje štěpení retrovirových polyproteinů, ale je kritická pro infektivitu viru, aktivitu reversní transkriptasy a sbalování nezralých virových částic. Tato doména je důležitá pro D-typ retrovirů. (cs) The C-terminal sequences of M-PMV protease contain a glycine-rich motif (G-patch), which binds in vitro to single-stranded nucleic acids. We found that the G-patch domain is not required for the processing of viral polyproteins, but it significantly influences the infectivity of M-PMV, the activity of reverse transcriptase, and assembly of immature capsid within the cells. The evolutionary conservation of the G-patch domain suggests its importance for retroviruses that display D-type morphology. The C-terminal sequences of M-PMV protease contain a glycine-rich motif (G-patch), which binds in vitro to single-stranded nucleic acids. We found that the G-patch domain is not required for the processing of viral polyproteins, but it significantly influences the infectivity of M-PMV, the activity of reverse transcriptase, and assembly of immature capsid within the cells. The evolutionary conservation of the G-patch domain suggests its importance for retroviruses that display D-type morphology. (en)
Title	The RNA binding G-patch domain in retroviral protease is important for infectivity and D-type morphogenesis of Mason-Pfizer monkey virus The RNA binding G-patch domain in retroviral protease is important for infectivity and D-type morphogenesis of Mason-Pfizer monkey virus (en) RNA vazebná doména retrovirové proteasy je důležitá pro infektivitu a D-typ morfologie opičího Mason-Pfizerova viru (cs)
skos:prefLabel	The RNA binding G-patch domain in retroviral protease is important for infectivity and D-type morphogenesis of Mason-Pfizer monkey virus The RNA binding G-patch domain in retroviral protease is important for infectivity and D-type morphogenesis of Mason-Pfizer monkey virus (en) RNA vazebná doména retrovirové proteasy je důležitá pro infektivitu a D-typ morfologie opičího Mason-Pfizerova viru (cs)
skos:notation	RIV/61388963:_____/05:00028127!RIV06-MSM-61388963
http://linked.open.../vavai/riv/strany	42106;42112
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(1M0520), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	51
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Pichová, Iva Zábranská, Helena Stříšovský, Kvido Ruml, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	541279
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/05:00028127
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	retroviral protease; RNA binding domain; M-PMV; infectivity; assembly (en)
http://linked.open.../riv/klicoveSlovo	M-PMV infectivity assembly retroviral protease RNA binding domain
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6FD1786E1737]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics Center for Applied Genomics
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	280
http://linked.open...iv/tvurceVysledku	Pichová, Iva Hunter, E. Ruml, Tomáš Štokrová, Jitka Bauerová, Helena Stříšovský, Kvido
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0021-9258
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The RNA binding G-patch domain in retroviral protease is important for infectivity and D-type morphogenesis of Mason-Pfizer monkey virus

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