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Description
| - Inter-individual differences in DNA repair capacity (DRC) pose an important source of variability in maintenance of genome integrity and thus influencing a predisposition to cancer. Aim of this study was to develop a simple, but comprehensive, nucleotide excision repair (NER)-specific challenge assay to measure DRC of DNA damage induced by Benzo[a]pyrene diolepoxide (BPDE). DRC has been evaluated in peripheral blood lymphocytes of 70 healthy individuals. In the same subjects, endogenous DNA damage in the form of single-strand breaks was measured. For the comparison of NER-specific DRC as a result of specific DNA damage induced by chemical and radiation stress, a parallel application of BPDE and ultraviolet (UV) light was conducted in a subgroup of 24 individuals.
- Inter-individual differences in DNA repair capacity (DRC) pose an important source of variability in maintenance of genome integrity and thus influencing a predisposition to cancer. Aim of this study was to develop a simple, but comprehensive, nucleotide excision repair (NER)-specific challenge assay to measure DRC of DNA damage induced by Benzo[a]pyrene diolepoxide (BPDE). DRC has been evaluated in peripheral blood lymphocytes of 70 healthy individuals. In the same subjects, endogenous DNA damage in the form of single-strand breaks was measured. For the comparison of NER-specific DRC as a result of specific DNA damage induced by chemical and radiation stress, a parallel application of BPDE and ultraviolet (UV) light was conducted in a subgroup of 24 individuals. (en)
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Title
| - DNA damage and nucleotide excision repair capacity
- DNA damage and nucleotide excision repair capacity (en)
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skos:prefLabel
| - DNA damage and nucleotide excision repair capacity
- DNA damage and nucleotide excision repair capacity (en)
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skos:notation
| - RIV/60162694:G44__/11:00002564!RIV12-MO0-G44_____
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(7F10069), P(GAP304/10/1286), S, V, Z(AV0Z50390512)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/11:00002564
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - BPDE-induced DNA repair capacity; comet assay; interindividual variability; biological and lifestyle characteristics; genetic polymorphism (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Environmental and Molecular Mutagenesis
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Lipská, Ludmila
- Naccarati, Alessio
- Pardini, Barbara
- Vodička, Pavel
- Vodičková, Ludmila
- Šmerhovský, Zdeněk
- Štětina, Rudolf
- Polaková, Veronika
- Scmuczerova, Jana
- Slyšková, Jana
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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is http://linked.open...avai/riv/vysledek
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