About: QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock

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About: QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We identified a novel clock-controlled gene (quasimodo), which encodes a light-responsive and membrane-anchored Zona Pellucida domain protein that supports light-dependent TIM degradation. Whereas wild type flies become arrhythmic in constant light (LL), quasimodo mutants elicit rhythmic expression of clock proteins and behavior in LL. QUASIMODO can function independently of CRY and is predominantly expressed within the CRY-negative DN3 clock neurons. Interestingly, downregulation of qsm in the clock circuit restores LL PERIOD protein rhythms in the qsm-negative DN1, indicating that qsm-mediated light-input is not cell-autonomous and can be accessed by the clock circuit. Our findings indicate that QUASIMODO constitutes part of a novel light-input to the circadian clock. Its light-responsive character in conjunction with the predicted localization at the outer neuronal membrane, suggests that QUASIMODO function is linked to electrical properties of clock neurons. We identified a novel clock-controlled gene (quasimodo), which encodes a light-responsive and membrane-anchored Zona Pellucida domain protein that supports light-dependent TIM degradation. Whereas wild type flies become arrhythmic in constant light (LL), quasimodo mutants elicit rhythmic expression of clock proteins and behavior in LL. QUASIMODO can function independently of CRY and is predominantly expressed within the CRY-negative DN3 clock neurons. Interestingly, downregulation of qsm in the clock circuit restores LL PERIOD protein rhythms in the qsm-negative DN1, indicating that qsm-mediated light-input is not cell-autonomous and can be accessed by the clock circuit. Our findings indicate that QUASIMODO constitutes part of a novel light-input to the circadian clock. Its light-responsive character in conjunction with the predicted localization at the outer neuronal membrane, suggests that QUASIMODO function is linked to electrical properties of clock neurons. (en)
Title	QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock (en)
skos:prefLabel	QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock (en)
skos:notation	RIV/60077344:_____/11:00367836!RIV12-MSM-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC07032), Z(AV0Z50070508), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Závodská, Radka Sehadová, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	225469
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00367836
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	QUASIMODO; Drosophila; circadian clock (en)
http://linked.open.../riv/klicoveSlovo	Drosophila QUASIMODO circadian clock
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B000BB0D7054]
http://linked.open...i/riv/nazevZdroje	Current Biology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Functional Genetics
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Sehadová, Hana Chen, K. F. Peschel, N. Stanewsky, R. Závodská, Radka
http://linked.open...ain/vavai/riv/wos	000290553800021
http://linked.open...n/vavai/riv/zamer	Study of the regulation of insect organism, dynamics of insect populations and function of insects in ecosystems EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	0960-9822
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.cub.2011.03.049
is http://linked.open...avai/riv/vysledek of	QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock

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