About: Futile import of tRNAs and proteins into the mitochondrion of Trypanosoma brucei evansi

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About: Futile import of tRNAs and proteins into the mitochondrion of Trypanosoma brucei evansi Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Trypanosoma brucei brucei has two distinct developmental stages, the procyclic stage in the insect and the bloodstream stage in the mammalian host. The significance of each developmental stage is punctuated by specific changes in metabolism. In the insect, T. b. brucei is strictly dependent on mitochondrial function and thus respiration to generate the bulk of its ATP, whereas in the mammalian host it relies heavily on glycolysis. Peculiarly, akinetoplastic strains of T. b. evansi that lack mitochondrial DNA do exist in the wild and are developmentally locked in the glycolysis-dependent bloodstream stage. Using RNAi we show that two mitochondrion-imported proteins, mitochondrial RNA polymerase and guide RNA associated protein 1, are still imported into the nucleic acids-lacking organelle of T. b. evansi, making the need for these proteins futile. Trypanosoma brucei brucei has two distinct developmental stages, the procyclic stage in the insect and the bloodstream stage in the mammalian host. The significance of each developmental stage is punctuated by specific changes in metabolism. In the insect, T. b. brucei is strictly dependent on mitochondrial function and thus respiration to generate the bulk of its ATP, whereas in the mammalian host it relies heavily on glycolysis. Peculiarly, akinetoplastic strains of T. b. evansi that lack mitochondrial DNA do exist in the wild and are developmentally locked in the glycolysis-dependent bloodstream stage. Using RNAi we show that two mitochondrion-imported proteins, mitochondrial RNA polymerase and guide RNA associated protein 1, are still imported into the nucleic acids-lacking organelle of T. b. evansi, making the need for these proteins futile. (en)
Title	Futile import of tRNAs and proteins into the mitochondrion of Trypanosoma brucei evansi Futile import of tRNAs and proteins into the mitochondrion of Trypanosoma brucei evansi (en)
skos:prefLabel	Futile import of tRNAs and proteins into the mitochondrion of Trypanosoma brucei evansi Futile import of tRNAs and proteins into the mitochondrion of Trypanosoma brucei evansi (en)
skos:notation	RIV/60077344:_____/11:00359409!RIV12-MSM-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA204/09/1667), P(LC07032), S, Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Lukeš, Julius Paris, Zdeněk Hashimi, Hassan Lun, Sijia
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	200671
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00359409
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Trypanosoma; tRNA; Protein import; Mitochondrion; Kinetoplast (en)
http://linked.open.../riv/klicoveSlovo	Kinetoplast Protein import tRNA Mitochondrion Trypanosoma
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[3CCFBA60C2F4]
http://linked.open...i/riv/nazevZdroje	Molecular and Biochemical Parasitology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Characterization of a novel protein complex involved in RNA processing and editing in the mitochondrion of Trypanosoma brucei Center for Functional Genetics
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	176
http://linked.open...iv/tvurceVysledku	Alfonzo, J. D. Lukeš, Julius Hashimi, Hassan Lun, Sijia Paris, Zdeněk
http://linked.open...ain/vavai/riv/wos	000288629800007
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	0166-6851
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.molbiopara.2010.12.010
is http://linked.open...avai/riv/vysledek of	Futile import of tRNAs and proteins into the mitochondrion of Trypanosoma brucei evansi

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