About: Casein kinase I epsilon somatic mutations found in breast cancer cause overgrowth in Drosophila

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Casein kinase I epsilon somatic mutations found in breast cancer cause overgrowth in Drosophila Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ijdb.ehu.es/web/paper.php?doi=093032td
Description	We are using a candidate gene approach to identify genes contributing to cancer through somatic mutation. Somatic mutations were found in breast cancer samples in the human casein kinase I epsilon (CKI epsilon) gene, a homolog of the Drosophila gene dco in which certain point mutations lead to imaginal disc overgrowth. We therefore created fly genotypes in which the dco gene carried point mutations homologous to those discovered in CKI epsilon, and tested them in vivo. The results show that the most frequent mutation discovered in breast cancer, L39Q, causes a striking overgrowth phenotype in flies. Further experiments show that this mutation affects the newly recognized Fat/Warts signaling pathway, which controls organ size and shape in both flies and mammals. Another mutation, S101R, modifies the mutant phenotype so that the affected tissue disintegrates, mimicking more aggressive forms of breast cancer. Our results thus strongly support the conclusion that CKI epsilon mutations play important roles in breast carcinogenesis. We are using a candidate gene approach to identify genes contributing to cancer through somatic mutation. Somatic mutations were found in breast cancer samples in the human casein kinase I epsilon (CKI epsilon) gene, a homolog of the Drosophila gene dco in which certain point mutations lead to imaginal disc overgrowth. We therefore created fly genotypes in which the dco gene carried point mutations homologous to those discovered in CKI epsilon, and tested them in vivo. The results show that the most frequent mutation discovered in breast cancer, L39Q, causes a striking overgrowth phenotype in flies. Further experiments show that this mutation affects the newly recognized Fat/Warts signaling pathway, which controls organ size and shape in both flies and mammals. Another mutation, S101R, modifies the mutant phenotype so that the affected tissue disintegrates, mimicking more aggressive forms of breast cancer. Our results thus strongly support the conclusion that CKI epsilon mutations play important roles in breast carcinogenesis. (en)
Title	Casein kinase I epsilon somatic mutations found in breast cancer cause overgrowth in Drosophila Casein kinase I epsilon somatic mutations found in breast cancer cause overgrowth in Drosophila (en)
skos:prefLabel	Casein kinase I epsilon somatic mutations found in breast cancer cause overgrowth in Drosophila Casein kinase I epsilon somatic mutations found in breast cancer cause overgrowth in Drosophila (en)
skos:notation	RIV/60077344:_____/10:00434963!RIV15-GA0-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/07/0814), Z(AV0Z50070508), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Doležal, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	249689
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/10:00434963
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Drosophila; breast cancer; Dco (en)
http://linked.open.../riv/klicoveSlovo	breast cancer Drosophila Dco
http://linked.open...odStatuVydavatele	ES - Španělské království
http://linked.open...ontrolniKodProRIV	[4569E166E767]
http://linked.open...i/riv/nazevZdroje	International Journal of Developmental Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Role of Casein Kinase Iepsilon in breast cancer
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Doležal, Tomáš Bryant, P. J. Kučerová, K. Neuhold, J.
http://linked.open...ain/vavai/riv/wos	000289665500003
http://linked.open...n/vavai/riv/zamer	Study of the regulation of insect organism, dynamics of insect populations and function of insects in ecosystems EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	0214-6282
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1387/ijdb.093032td

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 91 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software