About: SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions

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About: SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.springerlink.com/content/03353h53h300j70k/
Description	Heterochromatin protein 1 (HP1), which binds to sites of histone H3 lysine 9 (H3K9) methylation, is primarily responsible for gene silencing and the formation of heterochromatin. We observed that HP1beta is located in both the chromocenters and fibrillarin-positive nucleoli interiors. However, HP1alfa and HP1gamma occupied fibrillarin-positive compartments to a lesser extent, corresponding to the distinct levels of HP1 subtypes at the promoter of rDNA genes. Deficiency of histone methyltransferases SUV39h, and/or inhibition of histone deacetylases (HDACi) decreased HP1beta and H3K9 trimethylation at chromocenters, but not in fibrillarin-positive regions that co-localized with RNA Pol I. Similarly, SUV39h- and HDACi-dependent nucleolar rearrangement and inhibition of rDNA transcription did not affect the association between HP1beta - and fibrillarin. The presence of HP1beta in nucleoli is likely connected with transcription of ribosomal genes and with the role of fibrillarin in nucleolar processes. Heterochromatin protein 1 (HP1), which binds to sites of histone H3 lysine 9 (H3K9) methylation, is primarily responsible for gene silencing and the formation of heterochromatin. We observed that HP1beta is located in both the chromocenters and fibrillarin-positive nucleoli interiors. However, HP1alfa and HP1gamma occupied fibrillarin-positive compartments to a lesser extent, corresponding to the distinct levels of HP1 subtypes at the promoter of rDNA genes. Deficiency of histone methyltransferases SUV39h, and/or inhibition of histone deacetylases (HDACi) decreased HP1beta and H3K9 trimethylation at chromocenters, but not in fibrillarin-positive regions that co-localized with RNA Pol I. Similarly, SUV39h- and HDACi-dependent nucleolar rearrangement and inhibition of rDNA transcription did not affect the association between HP1beta - and fibrillarin. The presence of HP1beta in nucleoli is likely connected with transcription of ribosomal genes and with the role of fibrillarin in nucleolar processes. (en)
Title	SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions (en)
skos:prefLabel	SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions (en)
skos:notation	RIV/00216224:14330/10:00051235!RIV12-MSM-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040508), P(2B06052), P(LC535), P(ME 919), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Matula, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	291230
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/10:00051235
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SUV39h; heterochromatin protein 1; nucleoli; cell nucleus (en)
http://linked.open.../riv/klicoveSlovo	heterochromatin protein 1 nucleoli SUV39h cell nucleus
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[25642B71BD87]
http://linked.open...i/riv/nazevZdroje	Chromosoma
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Methylation of histone H3 as a prognostic marker of chronic myeloid leukemia remission Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20919
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	119
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Matula, Pavel Galiová, Gabriela Harničarová, Andrea Uhlířová, Radka
http://linked.open...ain/vavai/riv/wos	000277786400001
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0009-5915
number of pages	15 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00412-009-0252-2
http://localhost/t...ganizacniJednotka	14330
is http://linked.open...avai/riv/vysledek of	SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions

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