About: Local changes of higher-order chromatin structure during DSB-repair

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We show that double-strand breaks (DSBs) induced in DNA of human cells by gamma-radiation arise mainly in active, gene-rich, decondensed chromatin. We demonstrate that DSBs show limited movement in living cells, occasionally resulting in their permanent clustering, which poses a risk of incorrect DNA rejoining. In addition, some DSBs remain unrepaired for several days after irradiation, forming lesions repairable only with difficulty which are hazardous for genome stability. These late DSBs colocalize with heterochromatin markers (dimethylated histone H3 at lysine 9, HP1 and CENP-A proteins), despite the low density of the surrounding chromatin. This indicates that there is epigenetic silencing of loci close to unrepaired DSBs and/or stabilization of damaged decondensed chromatin loops during repair and post-repair reconstitution of chromatin structure. We show that double-strand breaks (DSBs) induced in DNA of human cells by gamma-radiation arise mainly in active, gene-rich, decondensed chromatin. We demonstrate that DSBs show limited movement in living cells, occasionally resulting in their permanent clustering, which poses a risk of incorrect DNA rejoining. In addition, some DSBs remain unrepaired for several days after irradiation, forming lesions repairable only with difficulty which are hazardous for genome stability. These late DSBs colocalize with heterochromatin markers (dimethylated histone H3 at lysine 9, HP1 and CENP-A proteins), despite the low density of the surrounding chromatin. This indicates that there is epigenetic silencing of loci close to unrepaired DSBs and/or stabilization of damaged decondensed chromatin loops during repair and post-repair reconstitution of chromatin structure. (en)
Title	Local changes of higher-order chromatin structure during DSB-repair Local changes of higher-order chromatin structure during DSB-repair (en)
skos:prefLabel	Local changes of higher-order chromatin structure during DSB-repair Local changes of higher-order chromatin structure during DSB-repair (en)
skos:notation	RIV/00216224:14310/08:00028599!RIV10-AV0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1P05OC084), P(1QS500040508), P(GP204/06/P349), P(IAA1065203), P(IAA500040802), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	101
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Gabrielová, Barbora Kozubek, Stanislav Falk, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	376999
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00028599
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DOUBLE-STRAND BREAKS; HIGH-RESOLUTION CYTOMETRY; DNA-DAMAGE; CHROMOSOME DOMAINS; ACTIVE GENES; NUCLEI; SITES; PROTEINS; CELLS; TRANSCRIPTION (en)
http://linked.open.../riv/klicoveSlovo	CELLS NUCLEI ACTIVE GENES CHROMOSOME DOMAINS HIGH-RESOLUTION CYTOMETRY SITES DOUBLE-STRAND BREAKS TRANSCRIPTION DNA-DAMAGE PROTEINS
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[65C251388B55]
http://linked.open...i/riv/nazevZdroje	JOURNAL OF PHYSICS CONFERENCE SERIES
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Dynamic structure and function of the cell nucleus after irradiation Methylation of histone H3 as a prognostic marker of chronic myeloid leukemia remission New mechanisms of oncoprotein action in genesis of promyelocytic leukemia Dynamic structure and function of the cell nucleus associated with DNA breaks The use of combination of laser microbeam and cytometric techniques in the study of the structure and dynamics of human genome
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	-
http://linked.open...iv/tvurceVysledku	Kozubek, Stanislav Lukášová, Emilie Ondřej, Vladan Falk, Martin Gabrielová, Barbora
http://linked.open...ain/vavai/riv/wos	BHW59
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	1742-6588
number of pages	18 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	Local changes of higher-order chromatin structure during DSB-repair Local changes of higher-order chromatin structure during DSB-repair Local changes of higher-order chromatin structure during DSB-repair Local changes of higher-order chromatin structure during DSB-repair

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