About: Chromatin dynamics during DSB repair

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Chromatin dynamics during DSB repair Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We show that double strand breaks (DSBs) induced in chromatin of low as well as high density by exposure of human cells to gama-rays are repaired in low-density chromatin. Only slight movement of sporadic DSB loci for short distances was noticed in living cells associated with chromatin decondensation around DSBs. This frequently resulted in their protrusion into the low-density chromatin domains. In these regions, the clustering (contact or fusion) of DSB foci was seen in vivo, and in situ after cell fixation. We propose that the repair of DSB in clustered foci might lead to misjoining of ends and, consequently, to exchange aberrations. We show that double strand breaks (DSBs) induced in chromatin of low as well as high density by exposure of human cells to gama-rays are repaired in low-density chromatin. Only slight movement of sporadic DSB loci for short distances was noticed in living cells associated with chromatin decondensation around DSBs. This frequently resulted in their protrusion into the low-density chromatin domains. In these regions, the clustering (contact or fusion) of DSB foci was seen in vivo, and in situ after cell fixation. We propose that the repair of DSB in clustered foci might lead to misjoining of ends and, consequently, to exchange aberrations. (en)
Title	Chromatin dynamics during DSB repair Chromatin dynamics during DSB repair (en)
skos:prefLabel	Chromatin dynamics during DSB repair Chromatin dynamics during DSB repair (en)
skos:notation	RIV/00216224:14310/07:00029518!RIV10-GA0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1P05OC084), P(1QS500040508), P(GP204/06/P349), P(IAA1065203), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Gabrielová, Barbora Kozubek, Stanislav Falk, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	413644
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00029518
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chromatin structure; DNA damage; double-strand breaks (DSB); DNA repair; exchange aberration; genomic instability (en)
http://linked.open.../riv/klicoveSlovo	chromatin structure DNA damage double-strand breaks (DSB) exchange aberration DNA repair genomic instability
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[3391D049F20A]
http://linked.open...i/riv/nazevZdroje	Biochimica et Biophysica Acta, Molecular Cell Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Dynamic structure and function of the cell nucleus after irradiation Methylation of histone H3 as a prognostic marker of chronic myeloid leukemia remission Dynamic structure and function of the cell nucleus associated with DNA breaks The use of combination of laser microbeam and cytometric techniques in the study of the structure and dynamics of human genome
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	1773
http://linked.open...iv/tvurceVysledku	Kozubek, Stanislav Lukášová, Emilie Ondřej, Vladan Falk, Martin Gabrielová, Barbora
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0167-4889
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	Chromatin dynamics during DSB repair Chromatin dynamics during DSB repair Chromatin dynamics during DSB repair

Faceted Search & Find service v1.16.116 as of Feb 22 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 82 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software