About: The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers

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About: The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Transcriptomic screens in breast cancer cell lines have identified a protein named anterior gradient-2 (AGR2) as a potentially novel oncogene overexpressed in estrogen receptor (ER) positive tumours. As targeting the ER is responsible for major improvements in cure rates and prevention of breast cancers, we have evaluated the prooncogenic function of AGR2 in anti-hormone therapeutic responses. We show that AGR2 expression promotes cancer cell survival in clonogenic assays and increases cell proliferation and viability in a range of cancer cell lines. Chromatin immunoprecipitation and reporter assays indicate that AGR2 is transcriptionally activated by estrogen through ER alpha. However, we also found that AGR2 expression is elevated rather than inhibited in response to tamoxifen, thus identifying a novel mechanism to account for an agonistic effect of the drug on a specific pro-oncogenic pathway. Transcriptomic screens in breast cancer cell lines have identified a protein named anterior gradient-2 (AGR2) as a potentially novel oncogene overexpressed in estrogen receptor (ER) positive tumours. As targeting the ER is responsible for major improvements in cure rates and prevention of breast cancers, we have evaluated the prooncogenic function of AGR2 in anti-hormone therapeutic responses. We show that AGR2 expression promotes cancer cell survival in clonogenic assays and increases cell proliferation and viability in a range of cancer cell lines. Chromatin immunoprecipitation and reporter assays indicate that AGR2 is transcriptionally activated by estrogen through ER alpha. However, we also found that AGR2 expression is elevated rather than inhibited in response to tamoxifen, thus identifying a novel mechanism to account for an agonistic effect of the drug on a specific pro-oncogenic pathway. (en)
Title	The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers (en)
skos:prefLabel	The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers (en)
skos:notation	RIV/00216224:14110/10:00051809!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GAP301/10/1615), P(NS9812), Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	34
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hrstka, Roman Vojtěšek, Bořivoj Petráková, Katarína Nenutil, Rudolf
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	282870
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00051809
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	AGR2; tamoxifen; letrozole; estrogen receptor; breast cancer (en)
http://linked.open.../riv/klicoveSlovo	AGR2 breast cancer letrozole tamoxifen estrogen receptor
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[75F17E7F2E7E]
http://linked.open...i/riv/nazevZdroje	Oncogene
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Rodina proteinů AGR2: úloha v biologii nádorové buňky Elucidating the role of ubiquitin-chaperone degradation machinery in cancer and modulating its biochemical functions using targeted chaperone inhibitors
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Hrstka, Roman Petráková, Katarína Vojtěšek, Bořivoj Nenutil, Rudolf Dixon, M. Fourtouna, A. Hupp, T. Langdon, S. Larionov, A. Maslon, M. Muller, P. Murray, E. Naughton, C.
http://linked.open...ain/vavai/riv/wos	000281326400009
http://linked.open...n/vavai/riv/zamer	Functional diagnostics of malignant tumours
issn	0950-9232
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/onc.2010.228
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers

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