About: Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains by whole genome fingerprinting: most of the genetic differences are localized in six genomic regions.

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About: Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains by whole genome fingerprinting: most of the genetic differences are localized in six genomic regions. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The genomes of eight treponemes including T. p. pallidum strains (Nichols, SS14, DAL1 and Mexico A), T. p. pertenue strains (Samoa D, CDC2 and Gauthier), and the FribourgBlanc isolate, were amplified in 133 overlapping amplicons, and the restriction patterns of these fragments were compared. The approximate genome sequence identity investigated based on this whole genome fingerprinting (WGF) analysis ranged from 99.57 to 99.98% in the homologous genome regions. Restriction target site analysis, detecting the presence of 1773 individual restriction sites found in the reference Nichols genome, revealed a high genome structure similarity of all strains. Most of the genetic differences between T. p. pallidum and T. p. pertenue strains were accumulated in six genomic regions. These genome differences likely contribute to the observed differences in pathogenicity between T. p. pallidum and T. p. pertenue strains and could be used for the molecular detection. The genomes of eight treponemes including T. p. pallidum strains (Nichols, SS14, DAL1 and Mexico A), T. p. pertenue strains (Samoa D, CDC2 and Gauthier), and the FribourgBlanc isolate, were amplified in 133 overlapping amplicons, and the restriction patterns of these fragments were compared. The approximate genome sequence identity investigated based on this whole genome fingerprinting (WGF) analysis ranged from 99.57 to 99.98% in the homologous genome regions. Restriction target site analysis, detecting the presence of 1773 individual restriction sites found in the reference Nichols genome, revealed a high genome structure similarity of all strains. Most of the genetic differences between T. p. pallidum and T. p. pertenue strains were accumulated in six genomic regions. These genome differences likely contribute to the observed differences in pathogenicity between T. p. pallidum and T. p. pertenue strains and could be used for the molecular detection. (en)
Title	Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains by whole genome fingerprinting: most of the genetic differences are localized in six genomic regions. Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains by whole genome fingerprinting: most of the genetic differences are localized in six genomic regions. (en)
skos:prefLabel	Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains by whole genome fingerprinting: most of the genetic differences are localized in six genomic regions. Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains by whole genome fingerprinting: most of the genetic differences are localized in six genomic regions. (en)
skos:notation	RIV/00216224:14110/10:00040816!RIV11-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/07/0321), P(NR8967), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Čejková, Darina Šmajs, David Zobaníková, Marie Strouhal, Michal Matějková, Petra Mikalová, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	260465
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00040816
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Treponema pallidum subsp. pallidum; Treponema pallidum subsp. pertenue; syphilis; yaws (en)
http://linked.open.../riv/klicoveSlovo	yaws syphilis Treponema pallidum subsp. pallidum Treponema pallidum subsp. pertenue
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[731FD833B1E9]
http://linked.open...i/riv/nazevZdroje	PloS ONE
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Genomics of Treponema: comparative genome sequencing of pathogenic treponemes and transcriptome analysis of T. pallidum ssp. pallidum Molecular typing of Treponema pallidum subsp. pallidum strains and isolates: the background for epidemiological and clinical identifications of individual strains
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Pospíšilová, Petra Strouhal, Michal Zobaníková, Marie Čejková, Darina Šmajs, David Mikalová, Lenka Norris, S. J. Sodergren, E. Weinstock, G. M.
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	1932-6203
number of pages	13 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains by whole genome fingerprinting: most of the genetic differences are localized in six genomic regions. Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains by whole genome fingerprinting: most of the genetic differences are localized in six genomic regions. Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains by whole genome fingerprinting: most of the genetic differences are localized in six genomic regions.

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