About: Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Syphilis spirochete Treponema pallidum ssp. pallidum remains the enigmatic pathogen, since no virulence factors have been identified and the pathogenesis of the disease is poorly understood. Increasing rates of new syphilis cases per year have been observed recently. The genome of the SS14 strain was sequenced to high accuracy by an oligonucleotide array strategy requiring hybridization to only three arrays (Comparative Genome Sequencing, CGS). Gaps in the resulting sequence were filled with targeted dideoxy-terminators (DDT) sequencing and the sequence was confirmed by whole genome fingerprinting (WGF). When compared to the Nichols strain, 327 single nucleotide substitutions (224 transitions, 103 transversions), 14 deletions, and 18 insertions were found. On the proteome level, the highest frequency of amino acid-altering substitution polymorphisms was in novel genes, while the lowest was in housekeeping genes, as expected by their evolutionary conservation. Syphilis spirochete Treponema pallidum ssp. pallidum remains the enigmatic pathogen, since no virulence factors have been identified and the pathogenesis of the disease is poorly understood. Increasing rates of new syphilis cases per year have been observed recently. The genome of the SS14 strain was sequenced to high accuracy by an oligonucleotide array strategy requiring hybridization to only three arrays (Comparative Genome Sequencing, CGS). Gaps in the resulting sequence were filled with targeted dideoxy-terminators (DDT) sequencing and the sequence was confirmed by whole genome fingerprinting (WGF). When compared to the Nichols strain, 327 single nucleotide substitutions (224 transitions, 103 transversions), 14 deletions, and 18 insertions were found. On the proteome level, the highest frequency of amino acid-altering substitution polymorphisms was in novel genes, while the lowest was in housekeeping genes, as expected by their evolutionary conservation. (en)
Title	Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays (en)
skos:prefLabel	Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays (en)
skos:notation	RIV/00216224:14110/08:00024748!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/07/0321), P(NR8967), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šmajs, David Strouhal, Michal Matějková, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	360760
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00024748
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Treponema pallidum ssp. pallidum; strain SS14; oligonucleotide arrays (en)
http://linked.open.../riv/klicoveSlovo	Treponema pallidum ssp. pallidum oligonucleotide arrays strain SS14
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1389FDB5AC73]
http://linked.open...i/riv/nazevZdroje	BMC Microbiology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Genomics of Treponema: comparative genome sequencing of pathogenic treponemes and transcriptome analysis of T. pallidum ssp. pallidum Molecular typing of Treponema pallidum subsp. pallidum strains and isolates: the background for epidemiological and clinical identifications of individual strains
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Norris, Steven J. Pospíšilová, Petra Strouhal, Michal Weinstock, George M. Šmajs, David Sodergren, Erica Palzkill, Timothy Albert, Thomas J. Molla, Michael N. Norton, Jason E. Petrosino, Joseph F. Richmond, Todd A. Singh, Jaz
http://linked.open...ain/vavai/riv/wos	000256297900001
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	1471-2180
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays

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