About: A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin.

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About: A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The antigenicity, structural location, and function of the predicted lipoprotein TP0136 of Treponema pallidum subsp. pallidum were investigated based on previous screening studies indicating that anti-TP0136 antibodies are present in the sera of syphilis patients and experimentally infected rabbits. Recombinant TP0136 (rTP0136) protein was purified and shown to be strongly antigenic during human and experimental rabbit infection. The TP0136 protein was exposed on the surface of the bacterial outer membrane and bound to the host extracellular matrix glycoproteins fibronectin and laminin. In addition, the TP0136 open reading frame was shown to be highly polymorphic among T. pallidum subspecies and strains at the nucleotide and amino acid levels. Finally, the ability of rTP0136 protein to act as a protective antigen to subsequent challenge with infectious T. pallidum in the rabbit model of infection was assessed. The antigenicity, structural location, and function of the predicted lipoprotein TP0136 of Treponema pallidum subsp. pallidum were investigated based on previous screening studies indicating that anti-TP0136 antibodies are present in the sera of syphilis patients and experimentally infected rabbits. Recombinant TP0136 (rTP0136) protein was purified and shown to be strongly antigenic during human and experimental rabbit infection. The TP0136 protein was exposed on the surface of the bacterial outer membrane and bound to the host extracellular matrix glycoproteins fibronectin and laminin. In addition, the TP0136 open reading frame was shown to be highly polymorphic among T. pallidum subspecies and strains at the nucleotide and amino acid levels. Finally, the ability of rTP0136 protein to act as a protective antigen to subsequent challenge with infectious T. pallidum in the rabbit model of infection was assessed. (en)
Title	A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin. A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin. (en)
skos:prefLabel	A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin. A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin. (en)
skos:notation	RIV/00216224:14110/08:00024747!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/07/0321), P(NR8967), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šmajs, David Matějková, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	354374
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00024747
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Treponema pallidum; protective antigen (en)
http://linked.open.../riv/klicoveSlovo	Treponema pallidum protective antigen
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DF25CF2CABBA]
http://linked.open...i/riv/nazevZdroje	INFECTION AND IMMUNITY
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Genomics of Treponema: comparative genome sequencing of pathogenic treponemes and transcriptome analysis of T. pallidum ssp. pallidum Molecular typing of Treponema pallidum subsp. pallidum strains and isolates: the background for epidemiological and clinical identifications of individual strains
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	76
http://linked.open...iv/tvurceVysledku	Norris, Steven J. Pospíšilová, Petra Weinstock, George M. Šmajs, David Brinkman, Mary Beth McGill, Melanie A. Palzkill, Timothy Pettersson, Jonas Rogers, Arthur
http://linked.open...ain/vavai/riv/wos	000255267200006
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	0019-9567
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin. A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin. A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin. A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin.

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