About: Genomics of Treponema.

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About: Genomics of Treponema. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The genus Treponema contains a number of disease-causing species. This includes T. pallidum pallidum (syphilis), T. pallidum pertenue (yaws), and T. pallidum endemicum (endemic syphilis, bejel) as well as T. carateum (pinta), T. paraluiscuniculi (rabbit treponematosis), and T. denticola (associated with periodontal disease). Many of these organisms differ from each other in only a few percent of their sequence, as judged by older hybridization studies, yet cause distinct diseases and pathologies. It is likely that the genetic bases for these pnenotypic differences results from subtle changes, possibly single base changes, rather than gain or loss of blocks of genes. Our aim has been to catalog genomic differences between these organisms as a starting point to pinpointing the genetic differences responsible for the infection phenotypes. We have sequenced several of these bacteria, using conventional as well as new methods, and have also performed genome wide comparisons by fingerprinting methods. The genus Treponema contains a number of disease-causing species. This includes T. pallidum pallidum (syphilis), T. pallidum pertenue (yaws), and T. pallidum endemicum (endemic syphilis, bejel) as well as T. carateum (pinta), T. paraluiscuniculi (rabbit treponematosis), and T. denticola (associated with periodontal disease). Many of these organisms differ from each other in only a few percent of their sequence, as judged by older hybridization studies, yet cause distinct diseases and pathologies. It is likely that the genetic bases for these pnenotypic differences results from subtle changes, possibly single base changes, rather than gain or loss of blocks of genes. Our aim has been to catalog genomic differences between these organisms as a starting point to pinpointing the genetic differences responsible for the infection phenotypes. We have sequenced several of these bacteria, using conventional as well as new methods, and have also performed genome wide comparisons by fingerprinting methods. (en)
Title	Genomics of Treponema. Genomics of Treponema. (en)
skos:prefLabel	Genomics of Treponema. Genomics of Treponema. (en)
skos:notation	RIV/00216224:14110/05:00013213!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/04/0021), P(NI7351), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šmajs, David Matějková, Petra
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	522608
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/05:00013213
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	T. pallidum pallidum; T. pallidum pertenue; T. pallidum endemicum; T. carateum (en)
http://linked.open.../riv/klicoveSlovo	T. carateum T. pallidum endemicum T. pallidum pallidum T. pallidum pertenue
http://linked.open...ontrolniKodProRIV	[AD2BB37FD1A4]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Postgenomic studies on Treponema pallidum, the syphilis spirochete Comparative genomics of pathogenic spirochetes of the genus Treponema: the route towards sequence-specific diagnostics
http://linked.open...UplatneniVysledku	2005
http://linked.open...iv/tvurceVysledku	Pospíšilová, Petra Šmajs, David Norris, S. J. Sodergren, E. Weinstock, G. M. Albert, T. J. Palzkill, T.
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
http://localhost/t...ganizacniJednotka	14110

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