About: Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Trichobilharzia regenti and T. szidati are schistosomes that infect birds. Although T. regenti/T. szidati can only complete their life cycle in specific bird hosts (waterfowl), their larvae-cercariae are able to penetrate, transform and then migrate as schistosomula in nonspecific hosts (e.g., mouse, man). Peptidases are among the key molecules produced by these schistosomes that enable parasite invasion and survival within the host and include cysteine peptidases such as cathepsins B1 and B2. These enzymes are indispensable bio-catalysts in a number of basal biological processes and host-parasite interactions, e.g., tissue invasion/migration, nutrition and immune evasion. Similar biochemical and functional characteristics were observed for cathepsins B1 and B2 in bird schistosomes (T. regenti, T. szidati) and also for their homologs in human schistosomes (Schistosoma mansoni, S. japonicum). Therefore, data obtained in the research of bird schistosomes can also be exploited for the control of human schistosomes such as the search for targets of novel chemotherapeutic drugs and vaccines. Trichobilharzia regenti and T. szidati are schistosomes that infect birds. Although T. regenti/T. szidati can only complete their life cycle in specific bird hosts (waterfowl), their larvae-cercariae are able to penetrate, transform and then migrate as schistosomula in nonspecific hosts (e.g., mouse, man). Peptidases are among the key molecules produced by these schistosomes that enable parasite invasion and survival within the host and include cysteine peptidases such as cathepsins B1 and B2. These enzymes are indispensable bio-catalysts in a number of basal biological processes and host-parasite interactions, e.g., tissue invasion/migration, nutrition and immune evasion. Similar biochemical and functional characteristics were observed for cathepsins B1 and B2 in bird schistosomes (T. regenti, T. szidati) and also for their homologs in human schistosomes (Schistosoma mansoni, S. japonicum). Therefore, data obtained in the research of bird schistosomes can also be exploited for the control of human schistosomes such as the search for targets of novel chemotherapeutic drugs and vaccines. (en)
Title	Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis (en)
skos:prefLabel	Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis (en)
skos:notation	RIV/00216208:11310/11:10107866!RIV12-GA0-11310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA206/07/0233), P(GD206/09/H026), P(LC06009), P(LC07032), S, Z(MSM0021620828)
http://linked.open...iv/cisloPeriodika	2011
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kašný, Martin Hampl, Vladimír Novotný, Marian Horák, Petr Dolečková, Kateřina Mikeš, Libor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	189301
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/11:10107866
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Schistosoma; migration; trematodes; cercarial dermatitis; bird schistosomes; Trichobilharzia; Cathepsin (en)
http://linked.open.../riv/klicoveSlovo	migration Cathepsin Schistosoma Trichobilharzia bird schistosomes cercarial dermatitis trematodes
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[50A2748FC6E7]
http://linked.open...i/riv/nazevZdroje	Advances in Experimental Medicine and Biology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Parasite-host relationships and the evolution of parasitism Center for Functional Genetics Biochemical, ultrastructural and partial proteomic analysis of the penetration apparatus of bird schistosome cercariae
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	712
http://linked.open...iv/tvurceVysledku	Dolečková, Kateřina Dvořák, Jan Hampl, Vladimír Horák, Petr Kašný, Martin Mikeš, Libor Novotný, Marian
http://linked.open...ain/vavai/riv/wos	000289378600009
http://linked.open...n/vavai/riv/zamer	Ekologické procesy v evoluci modelových skupin organismů
issn	0065-2598
number of pages	19 (xsd:int)
http://localhost/t...ganizacniJednotka	11310
is http://linked.open...avai/riv/vysledek of	Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis

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