About: Proconvulsant effect of aminophylline on cortical epileptic afterdischarges varies during ontogeny

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About: Proconvulsant effect of aminophylline on cortical epileptic afterdischarges varies during ontogeny Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/S0920-1211(99)00118-7
Description	Effect of aminophylline on epileptic afterdischarges (ADs) induced repeatedly by rhythmic electrical stimulation of sensorimotor cortical area was studied in rat pups 12, 18 and 25 days old. The proconvulsant effect of aminophylline (50 and/or 100 mg/kg i.p.) was more expressed in 12- and 18-day-old rats than in the oldest group. In 12-day-old rat pups there was an enormous increase of transition of the spike-and-wave type of ADs into the second, limbic type, a situation observed only exceptionally under control conditions. A prolongation of ADs was related to this transition (limbic ADs are always longer than spike-and-wave ones). Eighteen-day-old rats exhibit this transition less frequently but a marked prolongation of spike-and-wave ADs was recorded in a part of these animals forming a pattern of status lasting some tens of minutes. Aminophylline led only to a transient prolongation of spike-and-wave ADs in the oldest group. The transition into the limbic type of ADs was seen in this age group only Effect of aminophylline on epileptic afterdischarges (ADs) induced repeatedly by rhythmic electrical stimulation of sensorimotor cortical area was studied in rat pups 12, 18 and 25 days old. The proconvulsant effect of aminophylline (50 and/or 100 mg/kg i.p.) was more expressed in 12- and 18-day-old rats than in the oldest group. In 12-day-old rat pups there was an enormous increase of transition of the spike-and-wave type of ADs into the second, limbic type, a situation observed only exceptionally under control conditions. A prolongation of ADs was related to this transition (limbic ADs are always longer than spike-and-wave ones). Eighteen-day-old rats exhibit this transition less frequently but a marked prolongation of spike-and-wave ADs was recorded in a part of these animals forming a pattern of status lasting some tens of minutes. Aminophylline led only to a transient prolongation of spike-and-wave ADs in the oldest group. The transition into the limbic type of ADs was seen in this age group only (en)
Title	Proconvulsant effect of aminophylline on cortical epileptic afterdischarges varies during ontogeny Proconvulsant effect of aminophylline on cortical epileptic afterdischarges varies during ontogeny (en)
skos:prefLabel	Proconvulsant effect of aminophylline on cortical epileptic afterdischarges varies during ontogeny Proconvulsant effect of aminophylline on cortical epileptic afterdischarges varies during ontogeny (en)
skos:notation	RIV/00216208:11120/00:00003714!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IZ2209), P(IZ3510), P(KSK2011602), Z(AV0Z5011922), Z(MSM 111200005)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Bernášková, Klára
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	723541
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/00:00003714
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cerebral cortex; epileptic afterdischarges; theophylline; development; rat (en)
http://linked.open.../riv/klicoveSlovo	theophylline cerebral cortex development epileptic afterdischarges rat
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[75D962DDB5AF]
http://linked.open...i/riv/nazevZdroje	Epilepsy Research
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Can the administration of aminophyllin impair the outcome of epilepsy? Antiepileptic Therapy based on facilitation of inhibitory neuromodulators Brain and nervous systems
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	39
http://linked.open...iv/tvurceVysledku	Bernášková, Klára
http://linked.open...ain/vavai/riv/wos	000086837000002
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200005
issn	0920-1211
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/S0920-1211(99)00118-7
http://localhost/t...ganizacniJednotka	11120

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