About: Glycosphingolipid profile of the apical pole of human placental capillaries: The relevancy of the observed data to Fabry disease

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About: Glycosphingolipid profile of the apical pole of human placental capillaries: The relevancy of the observed data to Fabry disease Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1093/glycob/cws050
Description	Immunohistochemical study performed in a series of full-term placentas and umbilical cords showed uniform distinct staining of the apical membrane of villous capillary endothelial cells for globotriaosylceramide (Gb3Cer), GM1 ganglioside, GM3 ganglioside, cholesterol and caveolin 1. The immunophenotype suggests the presence of caveola-associated raft microdomains. In situ analysis of glycosphingolipids was paralleled by biochemical analysis and tandem mass spectrometry. The lipid in situ profile of placental villous capillaries was compared with that of endothelial cells of the uteroplacental vessels, umbilical vessels and with that in somatic capillaries. Gb3Cer expression in the placental blood villous capillaries represents a unique finding which points to specific features of their endothelial apical pole. Immunohistochemical study performed in a series of full-term placentas and umbilical cords showed uniform distinct staining of the apical membrane of villous capillary endothelial cells for globotriaosylceramide (Gb3Cer), GM1 ganglioside, GM3 ganglioside, cholesterol and caveolin 1. The immunophenotype suggests the presence of caveola-associated raft microdomains. In situ analysis of glycosphingolipids was paralleled by biochemical analysis and tandem mass spectrometry. The lipid in situ profile of placental villous capillaries was compared with that of endothelial cells of the uteroplacental vessels, umbilical vessels and with that in somatic capillaries. Gb3Cer expression in the placental blood villous capillaries represents a unique finding which points to specific features of their endothelial apical pole. (en)
Title	Glycosphingolipid profile of the apical pole of human placental capillaries: The relevancy of the observed data to Fabry disease Glycosphingolipid profile of the apical pole of human placental capillaries: The relevancy of the observed data to Fabry disease (en)
skos:prefLabel	Glycosphingolipid profile of the apical pole of human placental capillaries: The relevancy of the observed data to Fabry disease Glycosphingolipid profile of the apical pole of human placental capillaries: The relevancy of the observed data to Fabry disease (en)
skos:notation	RIV/00216208:11110/12:12690!RIV13-MZ0-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(NS10342), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Elleder, Milan Hůlková, Helena Honzíková, Jitka Kuchař, Ladislav Ledvinová, Jana Šmíd, František
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	138246
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/12:12690
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Fabry disease; gangliosides; glycosphingolipids; placental capillaries (en)
http://linked.open.../riv/klicoveSlovo	gangliosides placental capillaries Fabry disease glycosphingolipids
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[11A1714C841D]
http://linked.open...i/riv/nazevZdroje	Glycobiology
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Biochemistry and Cell Biology of Human Acetyl-Coenzyme A: Alpha-Glucosaminide N-Acetyltransferase – Basis for Future Therapeutic Applications in Mucopolysaccharidosis type IIIC
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Elleder, Milan Hůlková, Helena Honzíková, Jitka Kuchař, Ladislav Ledvinová, Jana Šmíd, František
http://linked.open...ain/vavai/riv/wos	000301976400013
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	0959-6658
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11110
is http://linked.open...avai/riv/vysledek of	Glycosphingolipid profile of the apical pole of human placental capillaries: The relevancy of the observed data to Fabry disease

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