About: Interferon-alpha treatment may negatively influence disease progression in melanoma patients by hyperactivation of STAT3 protein

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Interferon-alpha (IFN-alpha) is an important drug used in anti-melanoma therapy. However, metastases eventually reappear in almost 60% of melanoma patients, who have received adjuvant cytokine therapy suggesting that IFN-alpha can paradoxically promote disease progression in some cases, at least. In this study, we have investigated the possibility that a growth-promoting STAT3 protein might be activated by interferon-alpha in melanoma cells. Interferon-alpha (IFN-alpha) is an important drug used in anti-melanoma therapy. However, metastases eventually reappear in almost 60% of melanoma patients, who have received adjuvant cytokine therapy suggesting that IFN-alpha can paradoxically promote disease progression in some cases, at least. In this study, we have investigated the possibility that a growth-promoting STAT3 protein might be activated by interferon-alpha in melanoma cells. (en)
Title	Interferon-alpha treatment may negatively influence disease progression in melanoma patients by hyperactivation of STAT3 protein Interferon-alpha treatment may negatively influence disease progression in melanoma patients by hyperactivation of STAT3 protein (en)
skos:prefLabel	Interferon-alpha treatment may negatively influence disease progression in melanoma patients by hyperactivation of STAT3 protein Interferon-alpha treatment may negatively influence disease progression in melanoma patients by hyperactivation of STAT3 protein (en)
skos:notation	RIV/00209805:_____/09:#0000095!RIV10-MZ0-00209805
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/06/0912), Z(AV0Z50040507), Z(AV0Z50040702), Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Adámková, Lenka Kovařík, Jan Fait, Vuk Boudný, Vladimír Krejčí, Eva Lauerová, Ludmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	320028
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/09:#0000095
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Malignant melanoma, interferons, STAT3 activation, disease outcome (en)
http://linked.open.../riv/klicoveSlovo	STAT3 activation disease outcome interferons Malignant melanoma
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B833F57781D1]
http://linked.open...i/riv/nazevZdroje	European journal of cancer
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and functional perturbances of STAT/SOCS signaling pathways in breast cancer cells and their biological consequences.
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	45
http://linked.open...iv/tvurceVysledku	Krejčí, Eva Boudný, Vladimír Kovařík, Jan Fait, Vuk Humpolíková-Adámková, Lenka Lauerová, Ludmila
http://linked.open...ain/vavai/riv/wos	000266153600034
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Functional diagnostics of malignant tumours
issn	0014-2964
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Interferon-alpha treatment may negatively influence disease progression in melanoma patients by hyperactivation of STAT3 protein Interferon-alpha treatment may negatively influence disease progression in melanoma patients by hyperactivation of STAT3 protein Interferon-alpha treatment may negatively influence disease progression in melanoma patients by hyperactivation of STAT3 protein Interferon-alpha treatment may negatively influence disease progression in melanoma patients by hyperactivation of STAT3 protein

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