About: Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recently, a series of potent and selective neuronal nitric oxide synthase inhibitors containing two basic nitrogen atoms was reported (Ji, H.; Stanton, B. Z.; Igarashi, J.; Li, H.; Martasek, P.; Roman, L. J.; Poulos, T. L.; Silverman, R. B. J. Am. Chem. Soc. 2008, 130, 3900-3914). In an effort to improve their bioavailability, three compounds (2a-c) were designed with electron-withdrawing groups near one of the basic nitrogen atoms to lower its pK(a). Inhibition studies with these compounds showed that two of them not only retained most of the potency and selectivity of the best analogue of the earlier series, but also showed improved membrane permeability based on data from a cell-based assay. (C) 2009 Elsevier Ltd. All rights reserved. Recently, a series of potent and selective neuronal nitric oxide synthase inhibitors containing two basic nitrogen atoms was reported (Ji, H.; Stanton, B. Z.; Igarashi, J.; Li, H.; Martasek, P.; Roman, L. J.; Poulos, T. L.; Silverman, R. B. J. Am. Chem. Soc. 2008, 130, 3900-3914). In an effort to improve their bioavailability, three compounds (2a-c) were designed with electron-withdrawing groups near one of the basic nitrogen atoms to lower its pK(a). Inhibition studies with these compounds showed that two of them not only retained most of the potency and selectivity of the best analogue of the earlier series, but also showed improved membrane permeability based on data from a cell-based assay. (C) 2009 Elsevier Ltd. All rights reserved. (en)
Title	Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability (en)
skos:prefLabel	Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability (en)
skos:notation	RIV/00064165:_____/10:7010!RIV11-MZ0-00064165
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(1M0520), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Martásek, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	280459
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/10:7010
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Neuronal nitric oxide synthase; Selective inhibitors; Increased membrane permeability; pK(a); messenger-rna; disease (en)
http://linked.open.../riv/klicoveSlovo	Neuronal nitric oxide synthase disease pK(a) messenger-rna Increased membrane permeability Selective inhibitors
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C1142DF450DB]
http://linked.open...i/riv/nazevZdroje	Bioorganic & medicinal chemistry letters
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Applied Genomics
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Martásek, Pavel Roman, LJ Silverman, RB Xue, FT Fang, JG Lewis, WW
http://linked.open...ain/vavai/riv/wos	000272936000025
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	0960-894X
number of pages	4 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability

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