Attributes | Values |
---|
rdf:type
| |
Description
| - The facultative intracellular bacterium Francisella tularensis is the causal agent of the serious infectious disease tularemia. Despite intensive research, the pathogenetic mechanisms remain largely unknown. Generally, secreted proteins play an important role in pathogenicity of intracellular microbes. We investigated the protein composition of the culture filtrate proteins of highly virulent F. tularensis subsp. tularensis, strain SCHU S4 and attenuated F. tularensis subsp. holarctica, live vaccine strain using a comparative proteomic analysis. The majority of identified proteins have been implicated in virulence mechanisms of other pathogens, and several have been categorized as having moonlighting properties. Acid phosphatase (precursor) A (AcpA), beta-lactamase, and hypothetical protein FTT0484 were unique for the SCHU S4 strain. AcpA may be of importance for F. tularensis subsp. tularensis virulence due to the recently described AcpA role in the F. tularensis escape from phagosomes.
- The facultative intracellular bacterium Francisella tularensis is the causal agent of the serious infectious disease tularemia. Despite intensive research, the pathogenetic mechanisms remain largely unknown. Generally, secreted proteins play an important role in pathogenicity of intracellular microbes. We investigated the protein composition of the culture filtrate proteins of highly virulent F. tularensis subsp. tularensis, strain SCHU S4 and attenuated F. tularensis subsp. holarctica, live vaccine strain using a comparative proteomic analysis. The majority of identified proteins have been implicated in virulence mechanisms of other pathogens, and several have been categorized as having moonlighting properties. Acid phosphatase (precursor) A (AcpA), beta-lactamase, and hypothetical protein FTT0484 were unique for the SCHU S4 strain. AcpA may be of importance for F. tularensis subsp. tularensis virulence due to the recently described AcpA role in the F. tularensis escape from phagosomes. (en)
|
Title
| - Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains
- Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains (en)
|
skos:prefLabel
| - Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains
- Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains (en)
|
skos:notation
| - RIV/00027162:_____/10:#0000705!RIV11-MZE-00027162
|
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| - I, P(ME08105), V, Z(MO0FVZ0000501), Z(MO0FVZ0000604)
|
http://linked.open...iv/cisloPeriodika
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/10:#0000705
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| - Culture filtrate proteins; Francisella tularensis; Microbiology; Moonlighting proteins; Secreted proteins; Virulence factors (en)
|
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
|
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...i/riv/nazevZdroje
| |
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...vavai/riv/projekt
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Reichelová, Markéta
- Konečná, K.
- Alefantis, T.
- DelVecchio, V. G.
- Henrychová, L.
- Klimentova, J.
- Lenco, J.
- Macela, A.
- Stulík, J.
|
http://linked.open...ain/vavai/riv/wos
| |
http://linked.open...n/vavai/riv/zamer
| |
issn
| |
number of pages
| |
is http://linked.open...avai/riv/vysledek
of | |