| Attributes | Values |
|---|
| rdf:type
| |
| rdfs:seeAlso
| |
| Description
| - Post-translational modifications (PTM) of proteins play crucial role in the assembly, degradation, structure, and function of exprimed genes. PTM of proteins of bacterial pathogens strongly influence the nature of interaction with host cell system. However, little is known about the character and function of such modifications for intracellular bacteria. The main objective of the project is focused on the analysis of Francisella tularensis proteins, their post-translational modifications as glycosylation and phoshorylation. The aim of the research is to describe their structure in context with pathogenity and virulency of various subtypes of bacterial strains, differing in level of virulency. The strategy approach will be based on technologies that combine modern separation methods with mass spectrometry structure identification. The biofunctionalized magnetic nanoparticles with lectins, metal ions or specific mono(poly)clonal antibodies permit sufficient selectivity for glycosylated or phoshporylate (en)
- Cílem projektu je detekovat, identifikovat a charakterizovat proteiny bakterie Francisella tularensis posttranslačně modifikované glykosylací a fosforylací s využitím nově navržených nanotechnologických postupů separace a biospecifické koncentrace.
|
| Title
| - Differential proteome analysis of bacterial Francisella tularensis glyco- and phospho- proteins (en)
- Diferenciální proteomová analýza glyko- a fosfo- proteinů bakterie Francisella tularensis
|
| skos:notation
| |
| http://linked.open...avai/cep/aktivita
| |
| http://linked.open...kovaStatniPodpora
| |
| http://linked.open...ep/celkoveNaklady
| |
| http://linked.open...datumDodatniDoRIV
| |
| http://linked.open...i/cep/druhSouteze
| |
| http://linked.open...ep/duvernostUdaju
| |
| http://linked.open.../cep/fazeProjektu
| |
| http://linked.open...ai/cep/hlavniObor
| |
| http://linked.open...hodnoceniProjektu
| |
| http://linked.open...vai/cep/kategorie
| |
| http://linked.open.../cep/klicovaSlova
| - posttranslation modification; glycoprotein; phosphoprotein; Francisella tularensis; magnetic nanoparticles; mass spectrometry; comparative proteome analysis; database (en)
|
| http://linked.open...ep/partnetrHlavni
| |
| http://linked.open...inujicichPrijemcu
| |
| http://linked.open...cep/pocetPrijemcu
| |
| http://linked.open...ocetSpoluPrijemcu
| |
| http://linked.open.../pocetVysledkuRIV
| |
| http://linked.open...enychVysledkuVRIV
| |
| http://linked.open...lneniVMinulemRoce
| |
| http://linked.open.../prideleniPodpory
| |
| http://linked.open...iciPoslednihoRoku
| |
| http://linked.open...atUdajeProjZameru
| |
| http://linked.open.../vavai/cep/soutez
| |
| http://linked.open...usZobrazovaneFaze
| |
| http://linked.open...ai/cep/typPojektu
| |
| http://linked.open...ep/ukonceniReseni
| |
| http://linked.open.../cep/vedlejsiObor
| |
| http://linked.open...ep/zahajeniReseni
| |
| http://linked.open...jektu+dodavatelem
| - Projekt ME08105 byl zaměřen na charakterizaci proteinů bakterie Francisella tularensis modifikovaných glykosylací nebo fosforylací a navázání úzké spolupráce s renomovaným pracovištěm na Indiana University (Bloomington, IN, USA). (cs)
- ME08105 project was focused on the characterization of Francisella tularensis bacterial proteins modified by phosphorylation or glycosylation and a tight cooperation with Indiana University (Bloomington, IN, USA) has been established. (en)
|
| http://linked.open...tniCyklusProjektu
| |
| http://linked.open.../cep/klicoveSlovo
| - Francisella tularensis
- glycoprotein
- magnetic nanoparticles
- mass spectrometry
- comparative proteome analysis
- phosphoprotein
- posttranslation modification
|
| is http://linked.open...vavai/riv/projekt
of | |
| is http://linked.open...vavai/cep/projekt
of | |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)