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Description
| - Exposure to polycyclic aromatic hydrocarbons has been positively associated with prostate cancer, but knowledge of the formation of PAH-DNA adducts and related genotoxic events in prostatic cells is limited. In the present study, benzo[a]pyrene, formed significant levels of DNA adducts in cell lines derived from human prostate carcinoma. Despite a significant amount of DNA adducts being formed, neither apoptosis nor cell-cycle arrest were induced in LNCaP cells, presumably due to their failure to activate the p53-dependent DNA damage response. LNCaP cells were not sensitized to the induction of apoptosis by PAHs even through inhibition of the PI3K/Akt pro-survival pathway and the lack of apoptosis was not due a disruption of expression of pro-apoptotic and pro-survival members of the Bcl-2 family of apoptosis regulators. In contrast to other genotoxic stimuli, genotoxic PAHs failed to induce DNA double-strand breaks, as illustrated by the lack of phosphorylation of histone H2AX or Chk-2 activation.
- Exposure to polycyclic aromatic hydrocarbons has been positively associated with prostate cancer, but knowledge of the formation of PAH-DNA adducts and related genotoxic events in prostatic cells is limited. In the present study, benzo[a]pyrene, formed significant levels of DNA adducts in cell lines derived from human prostate carcinoma. Despite a significant amount of DNA adducts being formed, neither apoptosis nor cell-cycle arrest were induced in LNCaP cells, presumably due to their failure to activate the p53-dependent DNA damage response. LNCaP cells were not sensitized to the induction of apoptosis by PAHs even through inhibition of the PI3K/Akt pro-survival pathway and the lack of apoptosis was not due a disruption of expression of pro-apoptotic and pro-survival members of the Bcl-2 family of apoptosis regulators. In contrast to other genotoxic stimuli, genotoxic PAHs failed to induce DNA double-strand breaks, as illustrated by the lack of phosphorylation of histone H2AX or Chk-2 activation. (en)
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Title
| - Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells
- Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells (en)
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skos:prefLabel
| - Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells
- Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells (en)
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skos:notation
| - RIV/00027162:_____/10:#0000687!RIV11-GA0-00027162
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA310/07/0961), Z(AV0Z50040507), Z(AV0Z50040702), Z(AV0Z50390512), Z(AV0Z50390703), Z(MZE0002716202)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/10:#0000687
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Prostate epithelial cells; DNA adducts; Apoptosis; Cell-cycle arrest; p53; Carcinogenesis (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Vondráček, Jan
- Machala, Miroslav
- Topinka, J.
- Hrubá, Eva
- Krčmář, Pavel
- Marvanová, Soňa
- Milcová, A.
- Trilecová, Lenka
- Vykopalová, Lenka
- Libalová, H.
- Souček, K.
- Starsichova, A.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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