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| Description
| - In this study we analyzed the effects of 2,2´,4,4´,5,5´-hexachlorobiphenyl (PCB 153) on proteins involved in the formation of adherens junctions in WB-F344 cells. PCB 153 induced a gradual degradation of E-adherin, beta-catenin or plakoglobin proteins. PCB 153 had no effect on mRNA levels of the above mentioned proteins. PCB 153 also decreased levels of the active beta-catenin form, which is the key co-activator of Wnt-induced TCF/LEF-dependent gene expression and reduced Axin2 mRNA, a known Wnt signaling transcriptional target. Nevertheless, PCB 153 had no effect on phosphorylation of glycogen synthase kinase-3beta, which is supposed to target beta-catenin for its proteasomal degradation. Taken together, the present data suggest that PCB 153 may interfere with functions of adherens junction proteins involved in both cell-to-cell communication and intracellular signaling. Such mechanisms might be involved in the effects of non-dioxin-like PCBs contributing to liver tumor promotion.
- In this study we analyzed the effects of 2,2´,4,4´,5,5´-hexachlorobiphenyl (PCB 153) on proteins involved in the formation of adherens junctions in WB-F344 cells. PCB 153 induced a gradual degradation of E-adherin, beta-catenin or plakoglobin proteins. PCB 153 had no effect on mRNA levels of the above mentioned proteins. PCB 153 also decreased levels of the active beta-catenin form, which is the key co-activator of Wnt-induced TCF/LEF-dependent gene expression and reduced Axin2 mRNA, a known Wnt signaling transcriptional target. Nevertheless, PCB 153 had no effect on phosphorylation of glycogen synthase kinase-3beta, which is supposed to target beta-catenin for its proteasomal degradation. Taken together, the present data suggest that PCB 153 may interfere with functions of adherens junction proteins involved in both cell-to-cell communication and intracellular signaling. Such mechanisms might be involved in the effects of non-dioxin-like PCBs contributing to liver tumor promotion. (en)
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| Title
| - 2,2 ',4,4 ',5,5 '-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells
- 2,2 ',4,4 ',5,5 '-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells (en)
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| skos:prefLabel
| - 2,2 ',4,4 ',5,5 '-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells
- 2,2 ',4,4 ',5,5 '-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells (en)
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| skos:notation
| - RIV/00027162:_____/09:#0000569!RIV10-MZE-00027162
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA524/06/0517), Z(AV0Z50040507), Z(AV0Z50040702), Z(MZE0002716202)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/09:#0000569
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Polychlorinated biphenyls; E-cadherin; beta-Catenin; Adherens junctions; Canonical Wnt signaling; Rat liver progenitor cells (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Procházková, Jiřina
- Vondráček, Jan
- Machala, Miroslav
- Krčmář, Pavel
- Kozubík, A.
- Šimečková, Pavlína
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
of | - 2,2 ',4,4 ',5,5 '-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells
- 2,2 ',4,4 ',5,5 '-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells
- 2,2 ',4,4 ',5,5 '-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells
- 2,2 ',4,4 ',5,5 '-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells
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