About: Modern and conventional prognostic markers of chronic lymphocytic leukaemia in the everyday haematological practice

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1111/j.1600-0609.2011.01639.x
Description	The impact of modern prognostic markers on clinical course of chronic lymphocytic leukemia (CLL) in everyday practice has been not yet well-defined, especially in large series of patients. Therefore, the goal of the present study was to assess the influence of conventional as well as modern prognostic factors on overall survival (OS) and time to therapy (TTT) of CLL patients. Methods: We retrospectively analyzed data of all patients consecutively entered into the databases of five large academic centers in the Czech Republic. The total of 1300 patients was included in the analysis. Results and conclusion: Through the use of uniparametric analysis, it was determined that gender, clinical stage Rai II-IV, unmutated IgVH status, 17p deletion (for both 5% and 20% cut-off), 11q deletion, ZAP-70 positivity and high expression of CD38 had significant negative influence on OS. TTT was significantly influenced by gender, Rai stage, IgVH status, 11q deletion, 17p deletion, 13q deletion and by CD The impact of modern prognostic markers on clinical course of chronic lymphocytic leukemia (CLL) in everyday practice has been not yet well-defined, especially in large series of patients. Therefore, the goal of the present study was to assess the influence of conventional as well as modern prognostic factors on overall survival (OS) and time to therapy (TTT) of CLL patients. Methods: We retrospectively analyzed data of all patients consecutively entered into the databases of five large academic centers in the Czech Republic. The total of 1300 patients was included in the analysis. Results and conclusion: Through the use of uniparametric analysis, it was determined that gender, clinical stage Rai II-IV, unmutated IgVH status, 17p deletion (for both 5% and 20% cut-off), 11q deletion, ZAP-70 positivity and high expression of CD38 had significant negative influence on OS. TTT was significantly influenced by gender, Rai stage, IgVH status, 11q deletion, 17p deletion, 13q deletion and by CD (en)
Title	Modern and conventional prognostic markers of chronic lymphocytic leukaemia in the everyday haematological practice Modern and conventional prognostic markers of chronic lymphocytic leukaemia in the everyday haematological practice (en)
skos:prefLabel	Modern and conventional prognostic markers of chronic lymphocytic leukaemia in the everyday haematological practice Modern and conventional prognostic markers of chronic lymphocytic leukaemia in the everyday haematological practice (en)
skos:notation	RIV/00023736:_____/11:00009273!RIV12-MZ0-00023736
http://linked.open...avai/predkladatel	Ústav hematologie a krevní transfúze
http://linked.open...avai/riv/aktivita	I P V Z
http://linked.open...avai/riv/aktivity	I, P(NS10439), P(NS9858), P(NT11217), P(NT11218), V, Z(MSM0021620808), Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Schwarz, Jiří Trněný, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	213256
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/11:00009273
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chronic lymphocytic leukemia; cytogenetics; IgVh mutation status; prognostic markers; survival (en)
http://linked.open.../riv/klicoveSlovo	IgVh mutation status prognostic markers chronic lymphocytic leukemia survival cytogenetics
http://linked.open...odStatuVydavatele	DK - Dánské království
http://linked.open...ontrolniKodProRIV	[0CEA894AA591]
http://linked.open...i/riv/nazevZdroje	European Journal of Haematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of changes in genome and its expression in chronic lymphocytic leukemia patients during the disease development Prognostic stratification of CLL patients according to genetic alterations of TP53 gene - detection of mutations using functional analysis in combination with modern approaches The role of non-canonical Wnt signaling in molecular pathogenesis of chronic lymphocytic leukemia Functional and structural changes of microRNAs in lymphoproliferative malignancies and their impact on prognosis and prediction of therapy response
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	87
http://linked.open...iv/tvurceVysledku	Brejcha, M. Mayer, J. Trněný, Marek Brychtová, Y. Schwarz, Jiří Doubek, M. Pospíšil, Z. Cmunt, E. Kozmon, P. Obrtlíková, P. Pospíšilová, Š. Smolej, L.
http://linked.open...ain/vavai/riv/wos	000292778800005
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	0902-4441
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1600-0609.2011.01639.x
is http://linked.open...avai/riv/vysledek of	Modern and conventional prognostic markers of chronic lymphocytic leukaemia in the everyday haematological practice Modern and conventional prognostic markers of chronic lymphocytic leukaemia in the everyday haematological practice

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