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| Description
| - Aim of the project is to integrate the young researchers of the region (create %22Centrum of Excellence%22), which will be able to educate young scientific generation, to form the research projects of the top and world quality, and to define their progress.It is also aim of this project to built up a network of highly integrated laboratories of molecular biology and medicine which assure the quick transfer of the molecular biology methods in between. Research aims of the centrum are directed to %22Molecular basis of signalling and regulatory mechanisms of normal and malignant cells%22 and more specifically to the folowing aims: (1)molecular and regulatory mechanism of apoptosis; (2)regulation of activity of cyclin- dependent kinases; (3)function of p53 gene and its regulatory proteins;(4)signalling and regulatory role of polyamines, their metabolism and biochemistry; (5)photodynamic therapy of of cancers by active forms of oxygen; and (6)cell (en)
- Cílem projektu je integrace mozkového potenciálu mladých vědeckých pracovníků regionu (vytvořit %22Centrum of Excellence%22) na problematice %22molekulární podstaty signálních a regulačních mechanizmů normální a nádorové buňky%22. Zakládající tým bude školícím avýchovným kolektivem pro řádné a postgraduální studenty vysokých škol pro tento zásadní směr současné biologie.
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| Title
| - Profilation of the centrum of molecular and cellular biology and medicine of the Palacký University (CMBM UP). Research program and infrastructure (en)
- Profilování centra molekulární biologie a medicíny Univerzity Palackého (CMBM UP). Výzkumný program a infrastruktura
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open.../cep/klicovaSlova
| - molecular and cell biology, medicine, normal and cancer cell, cell cycle regulations,apoptoses, tumo (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...jektu+dodavatelem
| - Centrum molekulární biologie a medicíny se věnuje studiu molekul. podstaty signál. a regul. mechanismů normální a nádorové buňky, závislostí jejich patolog. změn na biolog. vlastnostech nádorů a vývoj nové generace farmak pro léčbu onkolog. onemocnění. (cs)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - medicine
- cell cycle regulations
- normal and cancer cell
- apoptoses
- molecular and cell biology
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| is http://linked.open...vavai/riv/projekt
of | - Laser-induced photodynamic effect
- Tumor supressor protein p53 binds preferentially to supercoiled DNA.
- Cytokinins as inhibitors of plant amine oxydase.
- Laser photodynamic treatment with phthallocyanines.
- Control of tumour development in plants and animals: a comparative treatise.
- Cytokinin oxidase: the key enzyme in the biodegradation of cytokinins.
- Cytotoxicita a fototoxicita ftalocyaninů
- Hodnocení lékové rezistence in vitro a její klinické implikace.
- The expression of apoptosis-related proteins and the apoptotic rate in glial tumors of the brain
- Expression of Bcl-2 in dysplastic and neoplastic cervical lesions in relation to cell proliferation and HPV infection
- Histochemické vyšetření aktivity některých enzymů v králičí rohovce po operaci LASIK
- Mechanisms of multidrug resistance and their clinical implications. II. Atypical MDR
- Mechanisms of multidrug resistance and their clinical implications. I. Typical MDR
- Molecular and biochemical properties of cytokinin dehydrogenase - enzyme activity degrading cytokinins in plants
- Precise characterisation of monoclonal antibodies to the C-terminal region of p53 protein using the PEPSCAN ELISA technique and a new non-radioactive gel shift assay.
- NMR Spectroscopy of 6-Benzylaminopurine Analogues. Part II. Complexation and Heteronuclear NMR
- NMR spectroscopy of 6-benzylaminopurine analogues. Part I: 15NMR study and protonation study.
- Relationship of apoptotic rate to BCL-2 expression and proliferation in breast cancer. Relationship of apoptotic rate to BCL-2 expression and proliferation in bre
- Synthesis, characterization and biological activity of two nickel(II) complexes with 6-(2-chlorobenzylamino)purine
- Barley Polyamine Oxidase: Characterisation and Analysis of the Cofactor and the N-terminal Amino Acid Sequence
- Preparation, physicochemical properties and biological activity of copper(II) complexes with 6-(2-chlorbenzylamino)purine (HL1) or 6-(3-chlorbenzylamino)purine (HL2). The single-crystal X-ray structure of [Cu(H(+)L2]2Cl3]Cl.2H2O
- Structural studies of 6-benzylaminopurine derivatives; Growth hormones with anti-tumor activity.
- The chemiexcitation of phthalocyanines for the photodynamic therapy by phthalhydrazide on the Gram-positive and Gram-negative bacteria
- In vitro phototoxicity testing in the Czech Republic
- Fluorescenční metody studia buněčného poškození.
- In vitro phototoxicity testing in the Czech Republic
- Penetration of the laser light into the skin in vitro
- SCGE analysis of genomic damage induced in cultured tobacco suspension cells by three purine analogues - Olomoucine, Bohemine and Roscovitine and by hedrogen peroxide, and ethyl methanesulfonate.
- Apoptosis-related proteins, BCL-2, BAX, FAS, FAS-L and PCNA in liver biopsies of patients with chronic hepatitis B virus infection
- Amine oxidase-based flow biosensor for the assessment of fish freshness
- Docking-Based Development of Purine-like Inhibitors of Cyclin-Dependent Kinase 2
- Electrooxidation mechanism of biogenic amines at amine oxidase modified graphite electrode
- Degradation of cytokinins by cytokinin oxidases in plants
- Laser-induced photodynamic effect
- Influence of genetic background on effectiveness/toxicity of current anticancer therapy
- Relation between expression of drug resistance associated proteins and results of cytotoxic in vitro MTT-assay in NSCLC patients
- Bio-active Cu(II), Pd(II) and Pt(II) complexes of 6-benzylaminopurine derivatives.
- Diagnostic algorithm for evalution of estrogen receptor functional ability in breast cancer.
- Cytokinin oxidase or dehydrogenase? Mechanism of cytokinin degradation in cereals
- In vivo metabolism of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine in mice: Glucosidation as the principal metabolic route.
- Inhibitors of Cyclin-dependent Kinases.
- Hodnocení buněčného poškození ve fluorescenčním inverzním mikroskopu
- Metal complexes as anticancer agents 2. Iron(III) and copper(II) bio-active complexes with N-6-benzylaminopurine derivatives
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| is http://linked.open...vavai/cep/projekt
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