About: Novel scaffolds for osteochondral regeneration based on core/shell nanofibers enriched with a drug delivery system     Goto   Sponge   NotDistinct   Permalink

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  • The objective of this study was to establish the system based on core/shell nanofibers enriched with liposomes as a novel drug delivery system for regeneration of osteochondral defects. Liposomes can be fulfilled with growth and differentiation factors. This system would lead to functionalization of nanofibers and presentation of nanofibers system with immobilized and anchored liposomes. We are counting on development of new system of intelligent cell scaffold with prolonged retention of bioactive bodies while being anriched by cells in conditions in vitro.. This approach is based on current research results and patents of Doc. RNDr. Evzen Amler, CSc. and his team. The project will be executed from 2011 to 2015 and the key outcome is prototype of new target delivery system. The benefits form this application will be not only for patients themselves, but also will save money for public insurence system. (en)
  • V rámci projektu bude vytvořen systém založený na dutých („core/shell”) nanovláknech obohacených o liposomy a PRP jako nového systému pro řízené dodávání léčiv především pro regeneraci osteochondrálních defektů. Tento postup, který je založen na stávajících dosažených výsledcích a patentech týmu řešitele Doc. RNDr. Evžena Amlera, CSc., povede k funkcionalizaci nanovláken a novému systému s imobilizovanými liposomy. Liposomy budou plněny růstovými a diferenciačními faktory. Počítáme s testováním nového systému jako inteligentního buněčného nosiče s prodlouženou retencí bioaktivníck látek při osídlování nosičů v podmínkách in vitro.
Title
  • Novel scaffolds for osteochondral regeneration based on core/shell nanofibers enriched with a drug delivery system (en)
  • Nanovlákenné nosiče s řízeným uvolňováním léčiv pro regeneraci osteochondrálních defektů
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  • NT12156
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  • tissue engineering; nanofibre scaffolds; liposomes; PRP; target delivery systems; arthritis (en)
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  • tissue engineering
  • liposomes
  • PRP
  • nanofibre scaffolds
  • target delivery systems
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