About: Specific metastatic site prediction due to the expression of %22homing%22 factors in circulating tumor cells in experimental metastatic models     Goto   Sponge   NotDistinct   Permalink

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Description
  • Project is going to characterize gene expression profiling of circulating tumor cells (CTC) in experimental mice metastatic models, with a special impact on gene expression of CTC homing factors. CTC are disseminated cells produced by primary tumor mostly, starting metastasing processes. CTC count in blood reflects the dynamics of the cancer disease. Based on the different mRNA oncogene expression in CTC we can monitor the whole process. The cells lines used to produce the experimental metastatic models in mice will be labelled by green fluorescent protein (GFP). Single cell gene expression analysis of primary tumor cells, circulating tumor cells and metastatic cells should help us to identify the subpopulation of circulating tumor cells, for which the genomic profile would be homing-specific, what would be of a crucial importance for new cancer treatment strategies. Single cell gene expression will be analyzed by unique qPCR system Biomark (Fluidigm Inc.) (en)
  • Predikce místa metastazování na základě exprese %22homing%22 faktorů u cirkulujících nádorových buněk v experimentálních myších modelech se speciálním zaměřením se na rakovinu prsu.
Title
  • Specific metastatic site prediction due to the expression of %22homing%22 factors in circulating tumor cells in experimental metastatic models (en)
  • Specifická predikce místa metastatického rozsevu na základě exprese 'homing' faktorů cirkulujících nádorových buněk v experimentálních nádorových modelech.
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  • ME10045
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  • green fluorescent protein; metastasing; circulating tumor cells; gene expression; homing; mice model (en)
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  • Development of the cultivation strategies for circulating tumor cells (CTCs)and disseminated tumor cells (DTCs) has enabled us to test the chemosensitivity differencies in the %22metastasing%22 cell populations in vitro thanks to the methodology of xCELLigence machine (Acea). The tumor cells have been co-cultured in the adipose tissue- a part of %22tumor microenvironment%22. (en)
  • Rozvíjení izolačních a kultivačních protokolů pro cirkulující nádorové buňky (CTCs) a diseminované nádorové buňky (DTCs) umožnilo detekovat rozdíly na poli buněčné proliferaci při testování účinku chemoterapeutických látek na jednotlivé populace %22metastatických%22 buněk v realním čase pomocí přístroje( xCELLigence, Acea) v kokultivaci s buňkami tukové tkáně jako složky %22tumor microenvironmentu%22. (cs)
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  • green fluorescent protein
  • gene expression
  • circulating tumor cells
  • homing
  • metastasing
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