About: Development of New Spontaneous Metastatic Heterotopic Model of Lewis Lung Carcinoma Imaged by GFP Expression

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.3109/07357907.2011.606247
Description	Many studies have demonstrated the importance of spontaneous metastases in cancer research. Until now, we still had only a few spontaneous metastatic models with high occurrence rate of metastasis in distant lymph and visceral tissues. We report a syngeneic heterotopic metastatic model using the Lewis lung cancer cell line with high metastatic ratio in C57BL/6 mice after transplantation by injection of cancer cells and without surgical intervention. Metastatic process was declared for each mouse in two groups -sacrificed 3 or 5 weeks after subcutaneous (s.c.) injection of the tumor cells into the dorsal side of the tail. The total number of metastases was counted as the sum of observed macrometastases. Our model produced produced a 100% rate of spontaneous lymphatic and visceral metastases after a simple injection transplantation into the heterotopic site. In mice with large primary tumors which are non-lethal, visceral and lymph macrometastases were observed. Many studies have demonstrated the importance of spontaneous metastases in cancer research. Until now, we still had only a few spontaneous metastatic models with high occurrence rate of metastasis in distant lymph and visceral tissues. We report a syngeneic heterotopic metastatic model using the Lewis lung cancer cell line with high metastatic ratio in C57BL/6 mice after transplantation by injection of cancer cells and without surgical intervention. Metastatic process was declared for each mouse in two groups -sacrificed 3 or 5 weeks after subcutaneous (s.c.) injection of the tumor cells into the dorsal side of the tail. The total number of metastases was counted as the sum of observed macrometastases. Our model produced produced a 100% rate of spontaneous lymphatic and visceral metastases after a simple injection transplantation into the heterotopic site. In mice with large primary tumors which are non-lethal, visceral and lymph macrometastases were observed. (en)
Title	Development of New Spontaneous Metastatic Heterotopic Model of Lewis Lung Carcinoma Imaged by GFP Expression Development of New Spontaneous Metastatic Heterotopic Model of Lewis Lung Carcinoma Imaged by GFP Expression (en)
skos:prefLabel	Development of New Spontaneous Metastatic Heterotopic Model of Lewis Lung Carcinoma Imaged by GFP Expression Development of New Spontaneous Metastatic Heterotopic Model of Lewis Lung Carcinoma Imaged by GFP Expression (en)
skos:notation	RIV/00216208:11120/11:00003182!RIV12-MZ0-11120___
http://linked.open...avai/predkladatel	3. lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ME10045), P(NS9976)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Pintérová, Daniela Bobek, Vladimír Kološtová, Katarína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	194078
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00003182
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	GFP (green fluorescent protein); Lewis lung cancer; Lymph node; Metastasis model; Metastasis; Spontaneous metastasis; Tumor (en)
http://linked.open.../riv/klicoveSlovo	GFP (green fluorescent protein) Lewis lung cancer Lymph node Metastasis model Spontaneous metastasis Tumor Metastasis
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[DC32F4836865]
http://linked.open...i/riv/nazevZdroje	Cancer Investigation
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Specific metastatic site prediction due to the expression of %22homing%22 factors in circulating tumor cells in experimental metastatic models Gene expression profiling in cancer circulating cells (CTCs) in breast carcinoma patients - a tool for early metastasis detection and therapy individualisation.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Bobek, Vladimír Kološtová, Katarína Pintérová, Daniela
http://linked.open...ain/vavai/riv/wos	000297024000006
issn	0735-7907
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.3109/07357907.2011.606247
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Development of New Spontaneous Metastatic Heterotopic Model of Lewis Lung Carcinoma Imaged by GFP Expression Development of New Spontaneous Metastatic Heterotopic Model of Lewis Lung Carcinoma Imaged by GFP Expression

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