About: Circulating Human Prostate Cancer Cells from an Orthotopic Mouse Model Rapidly Captured by Immunomagnetic Beads and Imaged by GFP Expression

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Circulating tumor cells (CTCs) are potential precursors of metastasis. They are also of use in diagnosing malignancy and for prognostic purposes. Our laboratory has previously isolated CTCs from orthotopic nude mouse models of human prostate cancer cells where the PC-3 cancer cells express green fluorescent protein (GFP). It was found that orthotopic tumors produced CTCs and not subcutaneous tumors, which may explain why orthotopic tumors metastasize and subcutaneous tumors do not. However, in this previous study, CTCs were observed only after culture. In the present study, using the GFP-expressing PC-3 orthotopic model and immunomagnetic beads coated with anti-epithelial cell adhesion molecule (EpCAM) and anti-prostate specific membrane antigen (PSMA), GFP-expressing CTC were isolated within 15 minutes and were readily visualized by GFP fluorescence. Circulating tumor cells (CTCs) are potential precursors of metastasis. They are also of use in diagnosing malignancy and for prognostic purposes. Our laboratory has previously isolated CTCs from orthotopic nude mouse models of human prostate cancer cells where the PC-3 cancer cells express green fluorescent protein (GFP). It was found that orthotopic tumors produced CTCs and not subcutaneous tumors, which may explain why orthotopic tumors metastasize and subcutaneous tumors do not. However, in this previous study, CTCs were observed only after culture. In the present study, using the GFP-expressing PC-3 orthotopic model and immunomagnetic beads coated with anti-epithelial cell adhesion molecule (EpCAM) and anti-prostate specific membrane antigen (PSMA), GFP-expressing CTC were isolated within 15 minutes and were readily visualized by GFP fluorescence. (en)
Title	Circulating Human Prostate Cancer Cells from an Orthotopic Mouse Model Rapidly Captured by Immunomagnetic Beads and Imaged by GFP Expression Circulating Human Prostate Cancer Cells from an Orthotopic Mouse Model Rapidly Captured by Immunomagnetic Beads and Imaged by GFP Expression (en)
skos:prefLabel	Circulating Human Prostate Cancer Cells from an Orthotopic Mouse Model Rapidly Captured by Immunomagnetic Beads and Imaged by GFP Expression Circulating Human Prostate Cancer Cells from an Orthotopic Mouse Model Rapidly Captured by Immunomagnetic Beads and Imaged by GFP Expression (en)
skos:notation	RIV/00216208:11120/11:00003170!RIV12-MZ0-11120___
http://linked.open...avai/predkladatel	3. lékařská fakulta
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ME 831), P(ME10045), P(NS9976), Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Pintérová, Daniela Bobek, Vladimír Kološtová, Katarína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	190445
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00003170
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	GFP; prostate cancer; PC-3; orthotopic; circulating cancer cells; immunomagnetic beads; isolation; fluorescence; imaging; culture (en)
http://linked.open.../riv/klicoveSlovo	GFP PC-3 circulating cancer cells culture fluorescence imaging immunomagnetic beads isolation orthotopic prostate cancer
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[9B41EC8E7D63]
http://linked.open...i/riv/nazevZdroje	Anticancer Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20831 Specific metastatic site prediction due to the expression of %22homing%22 factors in circulating tumor cells in experimental metastatic models Gene expression profiling in cancer circulating cells (CTCs) in breast carcinoma patients - a tool for early metastasis detection and therapy individualisation.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Bobek, Vladimír Kološtová, Katarína Pintérová, Daniela
http://linked.open...ain/vavai/riv/wos	000291235300004
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	0250-7005
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Circulating Human Prostate Cancer Cells from an Orthotopic Mouse Model Rapidly Captured by Immunomagnetic Beads and Imaged by GFP Expression Circulating Human Prostate Cancer Cells from an Orthotopic Mouse Model Rapidly Captured by Immunomagnetic Beads and Imaged by GFP Expression

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