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| rdfs:seeAlso
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| Description
| - The goals and expected results of the proposed project are directed to the field of studies on lectins from pathogens that are involved in the host cell recognition and binding, which may further result in invasion. In the first period of the research, we will focus our attention on bacterial lectins, mostly those from opportunistic pathogens, which are dangerous mainly for immunocompromised patients. In the second period, we will extend our studies also on viruses. Our goals will be not only to characterize the above interaction from the structure and function point of view, but mainly to design molecules that will “inhibit” these lectins and will, therefore, exhibit pharmacological effects. Within this direction, the main tool will be theoretical methods, essentially docking and sophisticated database search in libraries of existing compounds. Also in silico methods development within this direction will be included. (en)
- Cílem projektu je strukturně-funkční charakterizace interakcí lektinů z patogenních organismů a návrh „inhibitorů“ těchto lektinů s potenciálními farmakologickými účinky.
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| Title
| - Design of Carbohydrates and Glycomimetics as Antibacterial and Antiviral Drugs (en)
- Návrh antibakteriálních a antivirových léků na bázi cukrů a glykomimetik
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - lectins; pathogens; biomolecular interactions; X-ray structure; docking; molecular modelling (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Saccharides carry enormous information potential that is much wider compared to other biomolecules. Proteins that bind saccharides with high specificity are called lectins. These are involved in many key biological processes. In the framework of this project, we have prepared and characterized several lectins by measuring their affinity to selected saccharides. (en)
- Sacharidy nesou enormní informační potenciál, mnohonásobně větší než jiné typy biomolekul. Proteiny specificky vázající sacharidy se nazývají lektiny. Ty se účastní mnoha klíčových fyziologických procesů. V rámci projektu jsme připravili několik lektinů a měřili sílu jejich interakce s cukry. Proces interakce jsme modelovali teoretickými metodami, které jsme též vyvíjeli. (cs)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - lectins
- biomolecular interactions
- docking
- pathogens
- X-ray structure
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| is http://linked.open...vavai/riv/projekt
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| is http://linked.open...vavai/cep/projekt
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