About: Telomerase-independent mechanismus of telomere synthesis and loss

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=IAA600040505
Description	The plant family Alliaceae shows a remarkable variability of telomeres. While in some genera of this family the %22typical%22 plant telomers of (TTTAGGG)n sequence are substituted by human type of telomeres /TTAGGG)n and other variant motifs ([TTaGG]n,[TTGGG]n), in others (namely from the genus Allium) any known minisatellite telomere wequences are completely missing. Although it has been suggested that telomerisation in these species is ensured by satellite repeats or mobile elements by their amplification mechanisms, the terminal chromosome sequences have not been characterised in detail. The aim of the proposed project is therefore to characterise these sequences and their nucleoprotein complexes, and to detect intermediates of their amplification or of the reverse process called telomere rapid deletion. The working hypothesis is based on presumption that the oldest and evolutionary conserved mechanism of telomerisation is telomere loop present in a number of eukaryotes. (en) Rostlinná čeleď Alliaceae se vyznačuje značnou variabilitou telomer. Zatímco u řady rodů této čeledi jsou tzv. typické rostlinné telomery o sekvenci [TTTAGGG]n nahrazeny telomerami lidského typu [TTAGGG]n a dalšími variantními motivy ([TTAGG]n, [TTGGGG]n), u dalších zástupců, řazených zejm. do rodu Allium, zcela chybí jakékoli známé minisatelitní telomerové sekvence. Ačkoli bylo navrženo, že telomerizaci u těchto druhů zabezpečují satelitní repetice nebo mobilní elementy svými amplifikačními mechanismy, terminální sekvence chromozómů nebyly detailně charakterizovány. Cílem navrhovaného projektu je proto provést charakterizaci těchto sekvencí a jejich nukleoproteinových komplexů a detekovat intermediáty procesu amplifikace těchto sekvencí, event. opačného procesu zvaného rychlá ztráta telomer. Pracovní hypotéza je založena na předpokladu, že nejstarším a evolučně konzervovaným mechanismem telomerizace lineárních chromozómů je telomerová smyčka, prokázaná u řady eukaryot.
Title	Telomerase-independent mechanismus of telomere synthesis and loss (en) Mechanismy tvorby a ztráty telomer nezávislé na telomeráze
skos:notation	IAA600040505
http://linked.open...avai/cep/aktivita	Grants of distinctly investigative character focused on the sphere of research pursued at present particularly in the Academy of Sciences of the Czech Republic
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/IAA600040505/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/IAA600040505/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2010-06-08 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	65939834
http://linked.open...ai/cep/hlavniObor	EB - Genetika a molekulární biologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	plant telomeres; alternative telomere lengthening; chromatin structure; DNA; proteins; chromosomes; molecular analysis (en)
http://linked.open...ep/partnetrHlavni	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	48 (xsd:int)
http://linked.open...enychVysledkuVRIV	48 (xsd:int)
http://linked.open...lneniVMinulemRoce	2009-04-28 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/IAA600040505
http://linked.open...iciPoslednihoRoku	2009
http://linked.open...atUdajeProjZameru	2010
http://linked.open.../vavai/cep/soutez	SAV02005-A
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2009-12-31 (xsd:date)
http://linked.open...ep/zahajeniReseni	2005-01-01 (xsd:date)
http://linked.open...jektu+dodavatelem	U rostlin po ztrátě aktivity telomerázy byla prokázána aktivace alternativní tvorby telomer. Byly charakterizovány rostl. telomerázy syntetizující lidský typ telomer. U rostlin s typic. i alt. telomerami byly popsány tel. proteiny a jejich interakce. (cs) Activation of alternative telomere lengthening was shown in plants lacking telomerase activity. Plant telomerases producing human-type-telomeres were characterised. Tel. proteins and interactions were described in plants with typical or alt. telomeres. (en)
http://linked.open...tniCyklusProjektu	ZBBBKU
http://linked.open.../cep/klicoveSlovo	DNA alternative telomere lengthening chromatin structure chromosomes proteins plant telomeres
is http://linked.open...vavai/riv/projekt of	Telomere repeat binding protein variants show distinct kinetics and energetic nature of DNA-protein interaction Fate of telomere binding proteins after the loss of telomeres In vivo localisation of Arabidopsis thaliana Myb-like proteins Mapping of interaction domains of putative plant telomere preteins Origin and Evolution of Telomeres Structure-function relationships in telomerase genes Single integration and spread of a Copia-like sequence nested in rDNA intergenic spacers of Allium cernuum (Alliaceae) Comparison of expression profile of different protein constructs Plant telomeres and telomerases Characterization of telomere G-strand-binding proteins from the plant order Asparagales Characterization of nucleoprotein complexes in plants with human-type telomere motifs Charakterizace vazebných vlastností ATTRB1 Telomeres in evolution and evolution of telomeres Characterisation of AtTRB1 binding properties Role of alternative telomere lengthening unmasked in telomerase knock-out mutant plants Analysis of Telomeres and Telomerase Two faces of Solanaceae telomeres: a comparison between Nicotiana and Cestrum telomeres and telomere-binding proteins Evolution, Composition and Interrelated Functions of Telomeres and Subtelomeres: Lessons from Plants Protect and regulate: recent findings on plant POT1-like proteins Konce chromozomů u rostlinné čeledi Alliaceae Analysis of DNA-binding proteins by FRAP AND FLIP CESTRUM (Kladivník): zástupce dvouděložných rostlin s neobvyklými telomerami AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association with chromatin Comparison of transformation efficiency and expression profile of different protein constructs Minisatellite telomeres occur in the family Alliaceae but are lost in Allium Detection of telomerase activity by the TRAP assay and its variants and alternatives Asparagales telomerases which synthesize the human type of telomeres O polidštění rostlinných telomer Evoluční změny v syntéze rostlinných telomer Studium rostlinných proteinů in vivo Detekce ancestrálních telomerových proteinů u Cestrum parqui (Solanaceae) Usual and unusual telomeres Obvyklé a neobvyklé telomery Renaturation of telomere-binding proteins fractionated by SDS-polyacrylamide gel electrophoresis Solanaceae: model plant family for research in telomere biology Arabidopsis telomeric AtTRB1 protein is a nucleolar factor Renaturation of telomere-binding proteins after the fractionation by SDS-polyacrylamide gel electrophoresis Characterization of telomere G-strand-binding proteins from the plant order Asparagales Plant telomeres and telomerases Alternative telomere lengthening in development of normal and telomerase knock-out plants ALT in plant development In vivo dynamics of telomere-associated protein AtTRB1 Chromatin structure of typical and alternative telomeres Evolution of plant telomeres - step back or forward? Evolution of telomere synthesis in the plant order Asparagales Evolution of telomere synthesis in the plant order Asparagales Telomere-associated proteins of typical and alternative telomeres Allium cepa possess proteins able to bind the human- and Arabidopsis-type of telomeric sequence
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA600040505/2005/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA600040505/2006/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA600040505/2007/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA600040505/2008/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA600040505/2009/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA600040505/2010/ico%3A68081707

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