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| Description
| - During last decades and specifically several last years we observe growing frequency of disorders caused by abnormal regulation of immune mechanisms. The occurrence of such diseases boosts with astonishing speed. These conditions, that comprise allergies, autoimmune diseases and other entities including tumors, represent serious medical and social problem. Despite enormous research effort the underlying pathology in immune reactions and regulation was not yet elucidated. Current research project was designed to study etiology and pathogenesis of some immune mediated diseases, with the aim to contribute to the cumulative knowledge pertaining to the disrupted immune regulation. Such project requires multidisciplinary approach. Project proposal is based on intense and active cooperation of students from universities (1st and 2nd Medical Faculty and Faculty of Biological Sciences, Charles University) and Academy of Sciences (Institute of Microbiology and Institute of Molecular (en)
- V poslední době závratně stoupá výskyt onemocnění, která jsou způsobena poruchou regulace imunitních mechanismů. Do okruhu těchto chorob patří onemocnění alergická, autoimunitní a další, včetně nádorových. Přes výrazný pokrok základního výzkumu jsou patogenetické příčiny a zásahová místa poruch regulace u většiny onemocnění stále nejasné. Cílem navrhovaného projektu je přispět k objasnění etiologie a patogeneze mechanismů některých závažných chorob, což umožní zlepšit diagnózu a vyvinout nové typy cílených zásahů do regulačních mechanismů, které by mohly přispět k prevenci a léčbě těchto nemocí. Projekt vyžaduje interdisciplinární přístup a předpokládá proto intenzivní spolupráci doktorandů z universitních pracovišť UK (l.LF, 2. LF, PřF) a z Akademie věd ČR (Mikrobiologický ústav a Ústav molekulární genetiky). Na základě společných seminářů a výměny doktorandů v jednotlivých laboratořích a klinických pracovištích předpokládáme jak rozšíření metodické výbavy studentů, tak rozšíření jejich
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| Title
| - Regulatory mechanisms of the immune responses and their potential for development of new preventive and therapeutic strategies (en)
- Regulační mechanismy imunity a jejich využití pro nové preventivní a léčebné postupy
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Mapping of the genetic loci in atopic patients from Czech Republic, Ukraine and Siberia was performed. Molecules important for the innate immunity (fetidin, lysenin, CCF, calreticulin, lysozyme) in Eisenia fetida were characterized. New serological marke (en)
- U atopických pacientů z České republiky, Ukrajiny a Sibiře byly mapovány geny vnímavosti k atopické sensitizaci. U bezobratlých (Eisenia fetida) byly charakterizovány některé molekuly významné pro přirozenou imunitu (fetidin, lysenin, CCF, kalretikulin, (cs)
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| http://linked.open...tniCyklusProjektu
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| is http://linked.open...vavai/riv/projekt
of | - Gliadin stimulates human monocytes to production of IL-8 and TNF-alfa through a mechanism involving NF-kB
- Prevention of corneal allograft rejection in a mouse model of hight risk recipients
- Prevention of corneal allograft rejection in a mouse model of high risk recipients
- Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis
- Cytokine levels in healthy and allergic mothers and their children during the first year of life
- Immunomodulatory effects of Bacillus firmus on mouse peritoneal cells in vitro
- Effects of breast milk of healthy and allergic mothers on in vitro stimulation of cord blood lymphocytes
- Gliadin Peptides Activate Blood Monocytes from Patients with Celiac Disease
- Mouse model for analysis of non-MHC genes that influence allogeneic response: recombinant congenic strains of OcB/Dem series that carry identical H2 locus
- Production of nitric oxide during graft rejection is regulated by the TH1/Th2 balance, the arginase activity and L-arginine metabolism
- Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects
- Oral Administration of Probiotic Bacteria (E. coli Nissle, E. coli O83, Lactobacillus casei) Influences the Severity of Dextran Soium Sulfate-Induced Colitis in BALB/c Mice
- The activity of inducible nitric oxide synthase in rejected skin xenografts is selectively inhibited by a factor produced by grafted cells
- Expression of Toll-like receptor 2 (TLR2), TLR4 and CD14 in biopsy samples of patients with inflammatory bowel disease: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis.
- Prevention of allergy in infants of allergic mothers by probiotic Escherichia coli
- Susceptibility of corneal allografts and xenografts to antibody - mediated rejection
- Induction of systemic antitumour resistance with targeted polymers
- Involvement of Innate Immunity in the Development of Inflammatory and Autoimmune Diseases
- Interaction of Mucosal Microbiota with the Innate Immune System
- Induction of Systemic Antitumour Resistance with Targered Polymers
- Gliadin fragments induce phenotypic and functional maturation of human dendritic cells
- Mucosal immunity, intestinal microflora and inflammatory bowel disease
- Proteomic analysis of wheat proteins recognized by IgE antibodies of allergic patients
- Proteínové čipy pri štúdiu expresie cytokínov na nádorovom modele-optimalizácia prípravy vzoriek
- Anti-calreticulin immunoglobulin A (IgA) antibodies in refractory coeliac disease
- Antileukotrienic phenethylamido derivatives of arylalkanoic acids in the treatment of ulcerative colitis
- The Same Drug but a Different Mechanism of Action: Comparison of Free Doxorubicin with Two Different N-(2-Hydroxypropyl)methacrylamide Copolymer-Bound Doxorubicin Conjugates in EL-4 Cancer Cell Line
- Cat is a major allergen in patiens with asthma from west Siberia, Russia
- A new model of corneal transplantation in the miniature pig: Efficacy of imminosuppressive treatment
- Sledování produkce cytokinů v prvních letech života dětí nealergických a alergických matek
- Comparative study of the CCF-like pattern recognition protein in different Lumbricid species
- An invertebrate TNF functional analogue activates macrophages via lectin-saccharide interaction with ion channels
- Oral administration of probiotic bacteria (E. coli Nissle, E. coli O83, Lactobacillus casei) influences the severity of dextran sodium sulfate-induced colitis in Balb/c mice
- Cytokine profiling in human colostrum and milk by protein array
- Characterization, molecular cloning and localization of calreticulin in Eisenia fetida earthworms
- Multiplex analysis of cytokines involved in tumour growth and spontaneous regression in a rat sarcoma model
- Antileukotrienic N-arylethyl-2-arylacetamides in the treatment of ulcerative colitis
- Gluten and chronic diseases: Inflammatory activity of gluten
- Corneal rat-to-mouse xenotransplantation and the effects of anti-CD4 or anti CD8 treatment on cytokine and nitric oxide production
- Chemotherapy with HPMA Connjugate with pH-Controlled Release of Doxorubicin Exhibits reduced in Viva Toxicity and Induces Anti-Tumor Immunity
- T cell subsets play a vital role in generation of anti-tumor immunity induced in mice treated with antibody-targered HPMA copolymers containing doxorubicin
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| is http://linked.open...vavai/cep/projekt
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