About: The structure and properties of modified polymers for tissue engineering

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=GAP108/10/1106
Description	Interaction of cells with a polymer substrate is a complex process. Thus, the aim of this project is (i) activation of synthetic polymers by irradiation with plasma (UV-laser, ion beam), (ii) grafting of thiol-conjugated gold nanoparticles of various sizes and concentrations on these polymers, (iii) creation of gold nanoparticle-modified surfaces on soft and hard substrates applicable in blood vessel, skin and bone reconstruction, (iv) functionalization of thiols on gold nanoparticles with O- and N-containing groups, cell adhesion-mediating extracellular matrix proteins and oligopeptidic ligands for cell adhesion receptors, (v) characterization of all developed layers from the point of view of physicochemical properties important for cell-material interaction (e.g., surface roughness and morphology, wettability, electrical properties, chemical structure and composition, hardness etc.), and (vi) an evaluation of the adhesion, growth, differentiation, viability and potential immune activation of vascular, dermal and osteogenic cells in cultures on these materials. (en) Interakce buněk s polymerním substrátem je komplexní proces. Cílem tohoto projektu je (i) aktivace syntetických polymerů ozářením plasmou (UV-laserem, ionty), (ii) roubování aktivovaných polymerů zlatými nanočásticemi o různé velikosti a koncentraci, konjugovanými s thioly, (iii) vytvoření povrchů modifikovaných zlatými nanočásticemi na měkkých a tvrdých substrátech použitelných v rekonstrukci cév, kůže a kostí, (iv) funkcionalizace thiolů na zlatých nanočásticích skupinami obsahujícími kyslík a dusík, molekulami extracelulární matrix zprostředkujícími adhesi buněk a oligopeptidickými ligandy pro adhesní receptory buněk, (v) charakterizace vrstev z hlediska fyzikálně-chemických vlastností důležitých pro interakci mezi buňkou a materiálem (např. povrchová drsnost a morfologie, smáčivost, elektrické vlastnosti, chemická struktura a složení, tvrdost apod.) a (vi) hodnocení adhese, růstu, diferenciace, životaschopnosti a potenciální imunitní aktivace cévních, kožních a kostních buněk v kulturách na uvedených materiálech.
Title	The structure and properties of modified polymers for tissue engineering (en) Struktura a vlastnosti modifikovaných polymerů pro tkáňové inženýrství
skos:notation	GAP108/10/1106
http://linked.open...avai/cep/aktivita	Standard projects
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/GAP108%2F10%2F1106/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/GAP108%2F10%2F1106/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2015-05-22 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	100898612
http://linked.open...ai/cep/hlavniObor	JJ - Ostatní materiály
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	polymer modification structure and properties changes cells interaction (en)
http://linked.open...ep/partnetrHlavni	Fakulta chemické technologie
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	2 (xsd:int)
http://linked.open.../pocetVysledkuRIV	75 (xsd:int)
http://linked.open...enychVysledkuVRIV	75 (xsd:int)
http://linked.open...lneniVMinulemRoce	2014-04-18 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/P108-10-1106
http://linked.open...iciPoslednihoRoku	2014
http://linked.open...atUdajeProjZameru	2015
http://linked.open.../vavai/cep/soutez	SGA02010GA-ST
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2014-12-31 (xsd:date)
http://linked.open...ep/zahajeniReseni	2010-01-01 (xsd:date)
http://linked.open...jektu+dodavatelem	Všechny cíle projektu popsané v přihlášce byly splněny. V průběhu řešení byly získány původní výsledky o vlivu působení vysokoenergetického záření na vlastnosti pevných látek. Publikační aktivita řešitelů byla mimořádně vysoká ( 55xJimp+1xJneimp+6xC+1xP+74 ostatních mimo RIV+ 2Jimp byly zaslány k publikaci). Na základě uvedených skutečností panel P108 hodnotí řešení projektu stupněm vynikající. (cs) The aims of the project described in project proposal were completely fulfilled. The original results were obtained from the study of the high energy beams interaction and modification of solid material. Publication activity of team was exceptional (55xJimp+1xJneimp+6xC+1xP + 74 others publications, 2 Jimp were submitted for publication). Panel P108 evaluates obtained results as excellent. (en)
http://linked.open...tniCyklusProjektu	ZBBBKU
is http://linked.open...vavai/riv/projekt of	Plasma activated polymers grafted with cysteamine improving surfaces cytocompatibility Plasma and laser treatment of PMP for biocompatibility improvement Endothelial Cell Lining of PET Vascular Prostheses: Modification with Degradable Polyester-based Copolymers and Adhesive Protein Multi-layers The Gene Expression of Human Endothelial Cells Is Modulated by Subendothelial Extracellular Matrix Proteins: Short-Term Response to Laminar Shear Stress Properties of Au nanolayer sputtered on polyethyleneterephthalate From gold nano-particles through gold nano-wire to gold nano-layers on substrate Lattice parameter and expected density of Au nano-structures sputtered on glass Size dependent density of gold nano-clusters and nano-layers deposited on solid surface Different microscopy approach for solid surface characterization Electrokinetic Potential and Other Surface Properties of Polymer Foils and Their Modifications Electrokinetic Potential for Characterization of Nanosctructured Solid Fiat Surfaces Interaction of Polypropylene with Sputtered and Evaporated Au Nanolayers Calorimetry - supplementary method for study of surface properties Low pressure annealing of gold nanostructures Nanostructuring of Solid Surfaces The Properties and Application of Carbon Nanostructures Preparation and characterization of fully separated gold nanowire arrays Properties of silver nanostructure-coated PTFE and its biocompatibility Silver nano-structures prepared by oriented evaporation on laser-patterned poly(methyl methacrylate) From gold nano-particles through gold nano-wire to gold nano-layers Variable surface properties of PTFE foils Influence of substrate on properties of gold nanolayers Příprava nano-struktur na polymeru pro fotoniku Electrokinetic potential for polymer surfaces characterization Stanovení elektrokinetického potenciálu povrchů pevných látek EUV micropatterning for biocompatibility control of PET Annealing of gold nanostructures sputtered on glass substrate Annealing of sputtered gold nano-structures Au nanoparticles grafted on plasma treated polymers Angle dependent laser nanopatterning of poly(ethylene terephthalate) surfaces Annealing of gold nanostructures sputtered on polytetrafluoroethylene Nanoparticles on plasma treated PE for tissue engineering Nano-structuring of PTFE surface by plasma treatment, etching, and sputtering with gold Modulation of cell adhesion, proliferation and differentiation on materials designed for body implants Optical lattices prepared by laser treatment on polymers Preparation of nano-structures on polymer surface Self-organized gold nanostructures on laser patterned PET The role of smooth muscle cells in vessel wall pathophysiology and reconstruction using bioactive synthetic polymers XRD real structure characterization of sputtered Au films different in thickness Cell adhesion and proliferation on polyethylene grafted with Au nanoparticles Annealing of silver nanolayers sputtered on polytetrafluoroethylene Antibacterial properties of green-synthesized noble metal nanoparticles Annealing of laser patterned PMMA coated with gold and gallium Comparison of glow argon plasma-induced surface changes of thermoplastic polymers Transfer of thin, patterned gold layers from poly(methyl methacrylate) stamp onto photoresist surface %22Soft and rigid%22 dithiols and Au nanoparticles grafting on plasma-treated polyethyleneterephthalate Zeta potenciál na povrchu polymerních folií Gold nanostructures prepared on solid surface Plasma-Modified and Polyethylene Glycol-Grafted Polymers for Potential Tissue Engineering Applications PTFE surface modification by Ar plasma and its characterization Progressive approach for metal nanoparticle synthesis Volumetric behavior of the ternary system benzene-2-methoxy-2-methylbutane-2,2,4-trimethylpentane and all binary sub-systems at temperature range (298.15-318.15) K Characterization and cytocompatibility of carbon films The manipulation of carbon nanotubes on a polymer surface using a laser beam Nano-structuring of sputtered gold layers on glass by annealing Nanostructuring of polymer surface stimulated by laser beam for electronics and tissue engineering Nanostructuring of polymethylpentene by plasma and heat treatment for improved biocompatibility Determination of phase transition temperatures of nanostructured polymers Biopolymer nanostructures induced by plasma irradiation and metal sputtering Characterization of surface structures induced by: Laser, Plasma, Thermal treatment, Mettalization, Grafting Characterization of Surface Nanostructures on %22Thin%22 Polyolephine Foils Properties of gold nanostructures sputtered on glass Příprava a charakterizace 2D nanostruktur Ripple-like structure on PLLA induced by gold deposition and thermal treatment

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