About: Regulation of translation initiation during meiotic maturation of pig oocytes by protein factors associated with mRNA 3'-end     Goto   Sponge   NotDistinct   Permalink

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Description
  • Translation initiation is the rate-limiting step in the regulation of translation and it is influenced by cis-acting elements located primarily in the mRNA 5´ and 3´ untranslated regions - UTRs. As the factors regulating the mRNA binding to the ribosomes(i.e. factors acting at the mRNA 5'-end, the cap-binding protein complex eIF4F) have been studied by us extensively in the past, we will concentrate in the proposed project on the study of the role of polyadenylation and the factors associated with the mRNA 3'-end - cytoplasmic polyadenylation element binding protein (CPEB) and poly(A) binding protein (PABP) on the changes in translation rates. CPEB can act both as a repressor and an activator of cytoplasmic polyadenylation. Its activator function predominates, when it is phosphorylated by Aurora A kinase. This event induces CPEB to bind and recruit cleavage and polyadenylation specificity factor (CPSF), which in turn attracts poly(A) polymerase (PAP) to the end of the mRNA and in such a way (en)
  • Iniciace translace je limitujícím krokem regulace celkové translace proteinů a je ovlivňována tzv. %22cis-acting%22 elementy, které se nacházají na mRNA, na 5´ a 3´ nepřekládaných oblastech, tzv. UTRs. Vzhledem k tomu, že faktory účastnící se vazby mRNA na ribozomy (t.j. faktory působící na 5'-konci mRNA, tzv %22cap-binding%22 proteinový komplex eIF4F) byly v naší laboratoři v minulosti studovány poměrně intenzivně, soustředíme se v navrhovaném projektu na studium role polyadenylace a proteinových faktorů asociovaných s 3'-koncem mRNA - tzv. %22cytoplasmic polyadenylation element binding protein%22 (CPEB) a %22poly(A) binding protein%22 (PABP) na změny celkové translace. CPEB může působit buď jako aktivátor nebo jako repressor cytoplazmatické polyadenylace. Jako aktivátor působí, pokud je fosforylován protein kinázou Aurora A kinase. V důsledku této aktivace se CPEB váže na tzv. %22cleavage and polyadenylation specificity factor%22 (CPSF) a tento komplex pak způsobí připojení poly(A) polymerázy (PAP) na 3'-konec
Title
  • Regulation of translation initiation during meiotic maturation of pig oocytes by protein factors associated with mRNA 3'-end (en)
  • Regulace iniciace translace během meiotického zrání prasečích oocytů proteinovými faktory asociovanými s 3'-koncem mRNA
skos:notation
  • GA524/07/1087
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  • meiotic maturation; oocytes; translation initiation; polyadenylation (en)
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  • . (en)
  • Výsledkem projektu byly 3 práce s IF. Cíle projektu byly splněny. (cs)
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  • meiotic maturation
  • oocytes
  • translation initiation
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