About: Analysis of mRNA Associated factors During Bovine Oocyte Maturation and Early Embryonic Development     Goto   Sponge   NotDistinct   Permalink

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  • Regulation of gene expression at the translational level is particularly essential during developmental periods, when transcription is impaired. According to the closed-loop model of translational initiation, we have analyzed components of the 5'-mRNA cap-binding complex eIF4F (eIF4E, eIF4G, eIF4A), the eIF4E repressor 4E-BP1, and 3'-mRNA poly-(A) tail-associated proteins (PABP1 and 3, PAIP1 and 2, CPEB1, Maskin) during in vitro maturation of bovine oocytes and early embryonic development up to the 16-cell stage. Furthermore, we have elucidated the activity of distinct kinases which are potentially involved in their phosphorylation. Major phosphorylation of specific target sequences of PKA, PKB, PKC, CDKs, ATM/ATR, and MAPK were observed in M II stage oocytes. Furthermore, main changes in the abundance and/or phosphorylation of distinct mRNA-binding factors occur at the transition from M II stage oocytes to 2-cell embryos.
  • Regulation of gene expression at the translational level is particularly essential during developmental periods, when transcription is impaired. According to the closed-loop model of translational initiation, we have analyzed components of the 5'-mRNA cap-binding complex eIF4F (eIF4E, eIF4G, eIF4A), the eIF4E repressor 4E-BP1, and 3'-mRNA poly-(A) tail-associated proteins (PABP1 and 3, PAIP1 and 2, CPEB1, Maskin) during in vitro maturation of bovine oocytes and early embryonic development up to the 16-cell stage. Furthermore, we have elucidated the activity of distinct kinases which are potentially involved in their phosphorylation. Major phosphorylation of specific target sequences of PKA, PKB, PKC, CDKs, ATM/ATR, and MAPK were observed in M II stage oocytes. Furthermore, main changes in the abundance and/or phosphorylation of distinct mRNA-binding factors occur at the transition from M II stage oocytes to 2-cell embryos. (en)
Title
  • Analysis of mRNA Associated factors During Bovine Oocyte Maturation and Early Embryonic Development
  • Analysis of mRNA Associated factors During Bovine Oocyte Maturation and Early Embryonic Development (en)
skos:prefLabel
  • Analysis of mRNA Associated factors During Bovine Oocyte Maturation and Early Embryonic Development
  • Analysis of mRNA Associated factors During Bovine Oocyte Maturation and Early Embryonic Development (en)
skos:notation
  • RIV/67985904:_____/09:00337303!RIV10-AV0-67985904
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA524/07/1087), Z(AV0Z50450515)
http://linked.open...iv/cisloPeriodika
  • 12
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 302900
http://linked.open...ai/riv/idVysledku
  • RIV/67985904:_____/09:00337303
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • In Vitro maturation; Poly(A) binding protein; Initiation-factor 4E (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [A1F0E0323CAE]
http://linked.open...i/riv/nazevZdroje
  • Molecular Reproduction and Development
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 76
http://linked.open...iv/tvurceVysledku
  • Kubelka, Michal
  • Tomek, W.
  • Bhojawni, M.
  • Kanitz, W.
  • Leiding, C.
  • Siemer, C.
  • Smiljakovic, T.
http://linked.open...ain/vavai/riv/wos
  • 000271361500012
http://linked.open...n/vavai/riv/zamer
issn
  • 1040-452X
number of pages
is http://linked.open...avai/riv/vysledek of
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