About: Translational regulation by mRNA associated factors during bovine oocyte maturation and early embryonic development

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Translational regulation by mRNA associated factors during bovine oocyte maturation and early embryonic development Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Regulation of gene expression at the translational level is particularly essential during developmental periods, when transcription is impaired. According to the closed-loop model of translational initiation, we have analyzed components of the 5'-mRNA cap-binding complex eIF4F (eIF4E, eIF4G, eIF4A), the eIF4E repressor 4E-BP1, and 3'-mRNA poly-(A) tail-associated proteins (PABP1 and 3, PAIP1 and 2, CPEB1, Maskin) during in vitro maturation of bovine oocytes and early embryonic development up to the 16-cell stage. Furthermore, we have elucidated the activity of distinct kinases which are potentially involved in their phosphorylation. Major phosphorylation of specific target sequences of PKA, PKB, PKC, CDKs, ATM/ATR, and MAPK were observed in M II stage oocytes. Furthermore, main changes in the abundance and/or phosphorylation of distinct mRNA-binding factors occur at the transition from M II stage oocytes to 2-cell embryos. In conclusion, the results indicate that, at the transition from oocyte to e... Regulation of gene expression at the translational level is particularly essential during developmental periods, when transcription is impaired. According to the closed-loop model of translational initiation, we have analyzed components of the 5'-mRNA cap-binding complex eIF4F (eIF4E, eIF4G, eIF4A), the eIF4E repressor 4E-BP1, and 3'-mRNA poly-(A) tail-associated proteins (PABP1 and 3, PAIP1 and 2, CPEB1, Maskin) during in vitro maturation of bovine oocytes and early embryonic development up to the 16-cell stage. Furthermore, we have elucidated the activity of distinct kinases which are potentially involved in their phosphorylation. Major phosphorylation of specific target sequences of PKA, PKB, PKC, CDKs, ATM/ATR, and MAPK were observed in M II stage oocytes. Furthermore, main changes in the abundance and/or phosphorylation of distinct mRNA-binding factors occur at the transition from M II stage oocytes to 2-cell embryos. In conclusion, the results indicate that, at the transition from oocyte to e... (en)
Title	Translational regulation by mRNA associated factors during bovine oocyte maturation and early embryonic development Translational regulation by mRNA associated factors during bovine oocyte maturation and early embryonic development (en)
skos:prefLabel	Translational regulation by mRNA associated factors during bovine oocyte maturation and early embryonic development Translational regulation by mRNA associated factors during bovine oocyte maturation and early embryonic development (en)
skos:notation	RIV/67985904:_____/09:00337404!RIV10-AV0-67985904
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA524/07/1087), Z(AV0Z50450515)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kubelka, Michal
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	346765
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/09:00337404
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Oocyte maturation; Bovine embryo (en)
http://linked.open.../riv/klicoveSlovo	Bovine embryo Oocyte maturation
http://linked.open...ontrolniKodProRIV	[E10B48D33B5A]
http://linked.open...v/mistoKonaniAkce	Leipzig
http://linked.open...i/riv/mistoVydani	Malden
http://linked.open...i/riv/nazevZdroje	Reproduction in domestic animals
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Regulation of translation initiation during meiotic maturation of pig oocytes by protein factors associated with mRNA 3'-end
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Kubelka, Michal Tomek, W. Bhojawni, M. Siemer, C. Smiljakovic, T.
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2009-02-26 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture
issn	0936-6768
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Wiley-Blackwell
is http://linked.open...avai/riv/vysledek of	Translational regulation by mRNA associated factors during bovine oocyte maturation and early embryonic development Translational regulation by mRNA associated factors during bovine oocyte maturation and early embryonic development Translational regulation by mRNA associated factors during bovine oocyte maturation and early embryonic development Translational regulation by mRNA associated factors during bovine oocyte maturation and early embryonic development

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 77 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software