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| Description
| - Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA transcription. A variety of genetic events cause universal overactivity of the cell cycle cdks in human cancers, ant their inhibition can lead to both cell cycle arr (en)
- Cyclin-dependentní kinasy (cdk) jsou kritickými regulátory buněčného cyklu a transkripce. Nalezení olomoucinu jako prvního účinného inhibitoru cdk přinesl logicky vývoj nové generace protinádorových látek na antimitotickém základě, např. roskovitinu, olo
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| Title
| - Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors (en)
- Modulace buněčného dělení normálních a nádorových buněk inhibitory cyklin-dependentních kinas
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - cell; cycle; cyclin-dependent; kinases; cytotoxicity; cancerotoxicity; cancer (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Projekt výrazně přispěl k vývoji nových inhibitorů cyklin-dependentních kináz. Projekt vyprodukoval výrazné množství důležitých výsledků - údaje řešitele jsou adekvátní. Výsledky tohoto projektu by mohli mít teoreticky i klinické uplatnění. Z projektu vzešlo opravdu úctyhodné množství jak publikací v impaktovaných časopisech, tak i patentů. Celkově bych projekt panel označil za velice úspěšný. (cs)
- Project provided new inhibitors of cyclin-dependent kinases as well as insight into the structure-activity relation of these inhibitors. It also suggested new therapeutical use for these drugs, especially for inhibitors of CDK9. Thus, this project has also implication for development of clinically relevant drugs. A vast number of papers in impacted journals underlies the success of investigators. (en)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - cell
- cancerotoxicity
- cycle
- cyclin-dependent
- cytotoxicity
- kinases
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| is http://linked.open...vavai/riv/projekt
of | - 6, 9-disubstituted purine derivatives and their use for treating skin
- A Novel Roscovitine Derivative Potently Induces G(1)-Phase Arrest in Platelet-Derived Growth Factor-BB-Activated Vascular Smooth Muscle Cells
- The synthesis of androstane brassinosteroid analogues with alpha-azido acid ester groups in position 17beta
- Cytokinin receptor antagonists derived from 6-benzylaminopurine
- Hormonal control of the shoot stem-cell niche
- Cytotoxic Activities of Several Geranyl-Substituted Flavanones
- X-ray structure, NMR and stability-in-solution study of 6-(furfurylamino)-9-(tetrahydropyran-2-yl)purine - A new active compound for cosmetology
- Rhodococcus fascians Impacts Plant Development Through the Dynamic Fas-Mediated Production of a Cytokinin Mix
- Tandem mass spectrometry identification and LC-MS quantification of intact cytokinin nucleotides in K-562 human leukemia cells
- BRX promotes Arabidopsis shoot growth
- Low-light-induced Violaxanthin De-epoxidation in Shortly Preheated Leaves: Uncoupling from Delta pH-dependent Nonphotochemical Quenching
- Trisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors
- Endogenous cytokinins, auxins, and abscisic acid in red algae from Brazil
- H-1-, C-13-, and N-15-NMR chemical shifts for selected glucosides and ribosides of aromatic cytokinins
- Endogenous cytokinins in Cocos nucifera L. in vitro cultures obtained from plumular explants
- An improved in vivo deuterium labeling method for measuring the biosynthetic rate of cytokinins
- A seed coat bedding assay shows that RGL2-dependent release of abscisic acid by the endosperm controls embryo growth in Arabidopsis dormant seeds
- Cdk2 Inhibition Prolongs G1 Phase Progression in Mouse Embryonic Stem Cells
- A subset of cytokinin two-component signaling system plays a role in cold temperature stress response in Arabidopsis
- Role of 24-Epibrassinolide in Wheat Production: Physiological Effects and Uptake
- Endogenous brassinosteroids in wheat treated with 24-epibrassinolide
- Vacuolar and cytosolic cytokinin dehydrogenases of Arabidopsis thaliana: heterologous expression, purification and properties
- Degradation of cytokinins by maize cytokinin dehydrogenase is mediated by free radicals generated by enzymatic oxidation of natural benzoxazinones
- Pharmacological targeting of CDK9 in cardiac hypertrophy
- Analysis of 2-methylthio-derivatives of isoprenoid cytokinins by liquid chromatography-tandem mass spectrometry
- Phenyl- and benzylurea cytokinins as competitive inhibitors of cytokinin oxidase/dehydrogenase: a structural study
- Function of plant defense secondary metabolite in cytokinin degradation
- PIN phosphorylation is sufficient to mediate PIN polarity and direct auxin transport
- Structural and functional characterization of plant aminoaldehyde dehydrogenase from Pisum sativum with a broad specificity for natural and synthetic aminoaldehydes
- The first iron(III) complexes with cyclin-dependent kinase inhibitors: Magnetic, spectroscopic (IR, ES+ MS, NMR, Fe-57 Mossbauer), theoretical, and biological activity studies
- The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties
- Phytochemical and antimicrobial characterization of Macleaya cordata herb
- Cyclin-Dependent Kinase Inhibitors as Anticancer Drugs
- Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3-d]pyrimidines
- Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases
- Antioxidant potency of white (Brassica oleracea L. var. capitata) and Chinese (Brassica rapa L. var. pekinensis (Lour.)) cabbage: The influence of development stage, cultivar choice and seed selection
- Bacterial assay to study plant sensor histidine kinases
- The Arabidopsis YUCCA1 Flavin Monooxygenase Functions in the Indole-3-Pyruvic Acid Branch of Auxin Biosynthesis
- Investigation of new acyloxy derivatives of cholic acid and their esters as drug absorption modifiers
- In vitro interaction of a novel neutrophil growth factor with human liver microsomal cytochromes P450 and the contribution of UDP-glucuronosyltransferases to its metabolism
- Isolation of recombinant cysteine dioxygenase protein from Trichophyton mentagrophytes
- The selective P-TEFb inhibitor CAN508 targets angiogenesise
- Saccharide lupane derivatives, their use and pharmaceutical compositions containing these derivatives
- Stable transformation of Mesembryanthemum crystallinum (L.) with Agrobacterium rhizogenes harboring the green fluorescent protein targeted to the endoplasmic reticulum
- Substituované deriváty 6-(2-hydroxybenzylamino)purinu, jejich použití jako léčiva a farmaceutické přípravky tyto sloučeniny obsahující
- A cross-metathesis approach to the synthesis of new etretinate type retinoids, ethyl retinoate and its 9Z-isomer
- An apolar extract of Critonia morifolia inhibits c-Myc, cyclin D1 Cdc25A, Cdc25B, Cdc25C and Akt and induces apoptosis
- Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells
- Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines
- Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases
- Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy
- Anvendelse av 6-(4-hydroksybenzylamino)purin til kosmetiske formal
- Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy
- Nouveaux pyrazolo[4,3-D]pyrimidines, procedes pour leur preparation et methodes
- Substituted [1,2,3]triazolo[4,5-D]pyrimidines as CDK inhibitors
- Cytokinin regulates the activity of reproductive meristems, flower organ size, ovule formation, and thus seed yield in Arabidopsis thaliana
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