About: The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Olomoucine II, the most recent derivative of roscovitine, is an exceptionally potent pharmacological inhibitor of cyclin-dependent kinase activities. Here, we report that olomoucine II is also an effective antiviral agent. Olomoucine II inhibited replication of a broad range of wild-type human viruses, including herpes simplex virus, human adenovirus type-4 and human cytomegalovirus. Olomoucine II also inhibited replication of vaccinia virus and herpes simplex virus mutants resistant to conventional acyclovir treatment. This report is the first demonstration of a poxvirus being sensitive to a cyclin-dependent kinase inhibitor. The antiviral effects of olomoucine II could be observed at lower concentrations than with roscovitine, although both were short-term. A remarkable observation was that olomoucine II, when used in combination with the DNA polymerase inhibitor cidofovir, was able to almost completely eliminate the spread of infectious adenovirus type-4 progeny from infected cells. Olomoucine II, the most recent derivative of roscovitine, is an exceptionally potent pharmacological inhibitor of cyclin-dependent kinase activities. Here, we report that olomoucine II is also an effective antiviral agent. Olomoucine II inhibited replication of a broad range of wild-type human viruses, including herpes simplex virus, human adenovirus type-4 and human cytomegalovirus. Olomoucine II also inhibited replication of vaccinia virus and herpes simplex virus mutants resistant to conventional acyclovir treatment. This report is the first demonstration of a poxvirus being sensitive to a cyclin-dependent kinase inhibitor. The antiviral effects of olomoucine II could be observed at lower concentrations than with roscovitine, although both were short-term. A remarkable observation was that olomoucine II, when used in combination with the DNA polymerase inhibitor cidofovir, was able to almost completely eliminate the spread of infectious adenovirus type-4 progeny from infected cells. (en)
Title	The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties (en)
skos:prefLabel	The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties (en)
skos:notation	RIV/61389030:_____/10:00359317!RIV11-GA0-61389030
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/08/1649), P(LC06035), Z(AV0Z50380511), Z(MSM6198959216), Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kryštof, Vladimír Strnad, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	264009
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/10:00359317
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cyclin-dependent Kinase; Olomoucine II; vaccinia (en)
http://linked.open.../riv/klicoveSlovo	Cyclin-dependent Kinase Olomoucine II vaccinia
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2BC58C2D76C6]
http://linked.open...i/riv/nazevZdroje	Antiviral Chemistry and Chemotherapy
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine. Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Kryštof, Vladimír Strnad, Miroslav Hrstka, R. Vojtešek, B. Holčáková, J. Burget, J. J. Tomašec, P. Wang, E. C. Y. Wilkinson, G. W. G.
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Modulation of signalling and regulatory pathways in normal and cancer cells Functional diagnostics of malignant tumours
issn	0956-3202
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties

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