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Description
  • Výzkum vzájemné interakce dvou po sobě následujících rázových vln fokusovaných do společného ohniska. Výzkum interakce rázových vln s měkkými tkáněmi laboratorních zvířat, včetně tkání nádorových. Výzkum účinku rázových vln a kombinovaného účinku rázových vln a chemoterapie na růst nádorů.
  • The aim of the proposed project is to develop fundamental understanding of the mutual interaction of two successive shock waves focused to a common focal point - focused tandem shock waves (FTWS), their physical and chemical effects and their interactions with biological objects focused on the possible application of FTWS for cancer treatment and controlled drug delivery. For FTWS generation a novel type of generator will be used with ability to produce with adjustable delay two successive cylindrical pressure waves generated by underwater multichannel electrical discharge at a %22composite%22 anode that are focused by a metallic parabolic reflector (cathode) and transformed into a strong shock wave. We expect that collapsing cavitations created by the second wave in evolution of cavitations produced by the first wave create secondary, short wavelength shocks that can be able to interact with cell scale structures. We suppose that by this way it could be possible to increase efficiency of chemotherapy treatment of cancers. These assumptions will be tested on cell suspensions, soft animal tissues, including cancer tissues and with liposomes and ex vivo and in vivo experiments on laboratory animals. (en)
Title
  • Focused tandem shock waves and their potential application in cancer treatment and controlled drug delivery (en)
  • Dvě po sobě následující fokusované rázové vlny a jejich potenciální využití v terapii nádorů a řízeném uvolňování léčiv
skos:notation
  • GA202/09/1151
http://linked.open...avai/cep/aktivita
http://linked.open...kovaStatniPodpora
http://linked.open...ep/celkoveNaklady
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http://linked.open...i/cep/druhSouteze
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http://linked.open.../cep/klicovaSlova
  • elektrické výboje ve vodě, fokusované rázové vlny, kavitace, nádorové buňky, lipozomy (en)
http://linked.open...ep/partnetrHlavni
http://linked.open...inujicichPrijemcu
http://linked.open...cep/pocetPrijemcu
http://linked.open...ocetSpoluPrijemcu
http://linked.open.../pocetVysledkuRIV
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  • Řešení projektu proběhlo výtečně, jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
  • The project was excellent, both in terms of expertise and in terms of disbursement of funds. (en)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • fokusované rázové vlny
  • kavitace
  • nádorové buňky
  • elektrické výboje ve vodě
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